Potential of stem-cell-based therapies for heart disease

被引：108

作者：

Srivastava, D

Ivey, KN

机构：

[1] Univ Calif San Francisco, Gladstone Inst Cardiovasc Dis, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94158 USA

来源：

NATURE | 2006年 / 441卷 / 7097期

关键词：

D O I：

10.1038/nature04961

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The use of stem cells to generate replacement cells for damaged heart muscle, valves, vessels and conduction cells holds great potential. Recent identification of multipotent progenitor cells in the heart and improved understanding of developmental processes relevant to pluripotent embryonic stem cells may facilitate the generation of specific types of cell that can be used to treat human heart disease. Secreted factors from circulating progenitor cells that localize to sites of damage may also be useful for tissue protection or neovascularization. The exciting discoveries in basic science will require rigorous testing in animal models to determine those most worthy of future clinical trials.

引用

收藏

页码：1097 / 1099

页数：3

相关论文

共 35 条

[1]

*AM HEART ASS, 2004, HEART DIS STROK STAT, P11

[2] Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium [J].

Balsam, LB ;

Wagers, AJ ;

Christensen, JL ;

Kofidis, T ;

Weissman, IL ;

Robbins, RC .

NATURE, 2004, 428 (6983) :668-673

[3] Adult cardiac stem cells are multipotent and support myocardial regeneration [J].

Beltrami, AP ;

Barlucchi, L ;

Torella, D ;

Baker, M ;

Limana, F ;

Chimenti, S ;

Kasahara, H ;

Rota, M ;

Musso, E ;

Urbanek, K ;

Leri, A ;

Kajstura, J ;

Nadal-Ginard, B ;

Anversa, P .

CELL, 2003, 114 (06) :763-776

[4] Thymosin β4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair [J].

Bock-Marquette, I ;

Saxena, A ;

White, MD ;

DiMaio, JM ;

Srivastava, D .

NATURE, 2004, 432 (7016) :466-472

[5] Regulatory networks in embryo-derived pluripotent stem cells [J].

Boiani, M ;

Schöler, HR .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2005, 6 (11) :872-884

[6] ES cells derived from cloned and fertilized blastocysts are transcriptionally and functionally indistinguishable [J].

Brambrink, T ;

Hochedlinger, K ;

Bell, G ;

Jaenisch, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (04) :933-938

[7] Building the mammalian heart from two sources of myocardial cells [J].

Buckingham, M ;

Meilhac, S ;

Zaffran, S .

NATURE REVIEWS GENETICS, 2005, 6 (11) :826-835

[8] Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart [J].

Cai, CL ;

Liang, XQ ;

Shi, YQ ;

Chu, PH ;

Pfaff, SL ;

Chen, J ;

Evans, S .

DEVELOPMENTAL CELL, 2003, 5 (06) :877-889

[9] Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells [J].

Cowan, CA ;

Atienza, J ;

Melton, DA ;

Eggan, K .

SCIENCE, 2005, 309 (5739) :1369-1373

[10] A role for chemistry in stem cell biology [J].

Ding, S ;

Schultz, PG .

NATURE BIOTECHNOLOGY, 2004, 22 (07) :833-840

← 1 2 3 4 →