Flavonoids Protect Against Intercellular Adhesion Molecule-1 Induction by Benzo[a]pyrene

被引：10

作者：

Owens, Elizabeth Oesterling ^{[2
]}

Toborek, Michal ^{[3
]}

Hennig, Bernhard ^{[1
,2
]}

机构：

[1] Univ Kentucky, Coll Agr, Mol & Cell Nutr Lab, Lexington, KY 40536 USA

[2] Univ Kentucky, Coll Med, Grad Ctr Toxicol, Lexington, KY 40536 USA

[3] Univ Kentucky, Coll Med, Dept Neurosurg, Lexington, KY 40536 USA

来源：

BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY | 2009年 / 83卷 / 01期

关键词：

Benzo[a]pyrene; Flavonoids; Intercellular adhesion molecule-1; Atherosclerosis; ARYL-HYDROCARBON RECEPTOR; POLYCYCLIC AROMATIC-HYDROCARBONS; ENDOTHELIAL-CELLS; DEFICIENT MICE; HEART-DISEASE; ATHEROSCLEROSIS; ANTIOXIDANT; POLYPHENOLS; EXPRESSION;

D O I：

10.1007/s00128-009-9664-1

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Dietary changes are an attractive means of protecting against environmental chemical exposure. Exposure to benzo[a]pyrene (B[a]P) is a risk factor for cardiovascular disease events. It has recently been shown that B[a]P can increase intercellular adhesion molecule-1 (ICAM-1) in endothelial cells, a possible means of promoting cardiovascular disease. This study investigated the ability of flavonoids to protect against B[a]P-induced ICAM-1. It was shown that only flavonoids that contain a 4' B-ring hydroxyl substitution and a 2-3 C-ring double bond were protective. These data suggest that selected bioactive compounds can decrease proinflammatory properties of environmental chemicals such as B[a]P.

引用

页码：4 / 7

页数：4

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