Enhancement of water-solubility and bioactivity of paclitaxel using modified cyclodextrins

被引：81

作者：

Hamada, Hiroki

Ishihara, Kohji

Masuoka, Noriyoshi

Mikuni, Katsuhiko

Nakajima, Nobuyoshi

机构：

[1] Okayama Univ Sci, Dept Life Sci, Okayama 7000005, Japan

[2] Ensuiko Sugar Refining Co Ltd, Carbohydrate Res Lab, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan

[3] Okayama Prefectural Univ, Reg Cooperat Res Org, Ind Govt & Acad Promot Ctr, Okayama 7191197, Japan

来源：

JOURNAL OF BIOSCIENCE AND BIOENGINEERING | 2006年 / 102卷 / 04期

关键词：

paclitaxel; cyclodextrin; inclusion complex; water solubility;

D O I：

10.1263/jbb.102.369

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We investigated the aqueous solubility of paclitaxel using 11 kinds of cyclodextrins (CDs) and the bioactivity of the paclitaxel-CD inclusion complex. 2,6-Dimethyl beta-cyclodextrin was the most effective and its solubility was 2.3 mM in a 0.1 M 2,6-dimethyl beta-cyclodextrin aqueous solution. The inclusion complex of paclitaxel and 2,6-dimethyl beta-cyclodextrin had a 1.23-fold polymerization activity as paclitaxel in a tubulin assay.

引用

页码：369 / 371

页数：3

共 12 条

[1] INTERACTION OF TAXOL AND OTHER ANTICANCER DRUGS WITH HYDROXYPROPYL-BETA-CYCLODEXTRIN [J].