Sarcopenia and hypertrophy: A role for insulin-like growth factor-1 in aged muscle?

被引：49

作者：

Hameed, M

Harridge, SDR

Goldspink, G

机构：

[1] UCL, Royal Free & Univ Coll Med Sch, Dept Physiol, London NW3 2PF, England

[2] UCL, Royal Free & Univ Coll Med Sch, Dept Anat & Dev Biol, London NW3 2PF, England

来源：

EXERCISE AND SPORT SCIENCES REVIEWS | 2002年 / 30卷 / 01期

关键词：

muscle; strength; growth factors; aging; protein synthesis;

D O I：

10.1097/00003677-200201000-00004

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Sarcopenia is the loss of muscle mass associated with the aging process. Although systemic or circulating growth hormone and insulin-like growth factor-1 levels fall as we age, this is likely to be of lesser importance in regard to muscle mass than the rule of locally produced insulin-like growth factor-Is generated in the muscle in response to exercise.

引用

收藏

页码：15 / 19

页数：5

相关论文

共 16 条

[1] Localized infusion of IGF-I results in skeletal muscle hypertrophy in rats [J].

Adams, GR ;

McCue, SA .

JOURNAL OF APPLIED PHYSIOLOGY, 1998, 84 (05) :1716-1722

[2] Regulation of IGF-I, IGFBP-4 and IGFBP-5 gene expression by loading in mouse skeletal muscle [J].

Awede, B ;

Thissen, JP ;

Gailly, P ;

Lebacq, J .

FEBS LETTERS, 1999, 461 (03) :263-267

[3] Effects of aging on in vivo synthesis of skeletal muscle myosin heavy-chain and sarcoplasmic protein in humans [J].

Balagopal, P ;

Rooyackers, OE ;

Adey, DB ;

Ades, PA ;

Nair, KS .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 1997, 273 (04) :E790-E800

[4] Replicative potential and telomere length in human skeletal muscle: Implications for satellite cell-mediated gene therapy [J].

Decary, S ;

Mouly, V ;

BenHamida, C ;

Sautet, A ;

Barbet, JP ;

ButlerBrowne, GS .

HUMAN GENE THERAPY, 1997, 8 (12) :1429-1438

[5] ACTIVATION OF INSULIN-LIKE GROWTH-FACTOR GENE-EXPRESSION DURING WORK-INDUCED SKELETAL-MUSCLE GROWTH [J].

DEVOL, DL ;

ROTWEIN, P ;

SADOW, JL ;

NOVAKOFSKI, J ;

BECHTEL, PJ .

AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 259 (01) :E89-E95

[6]

Fiatarone Singh Maria A., 1999, American Journal of Physiology, V277, pE135

[7] Expression of insulin growth factor-1 splice variants and structural genes in rabbit skeletal muscle induced by stretch and stimulation [J].

McKoy, G ;

Ashley, W ;

Mander, J ;

Yang, SY ;

Williams, N ;

Russell, B ;

Goldspink, G .

JOURNAL OF PHYSIOLOGY-LONDON, 1999, 516 (02) :583-592

[8] Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle [J].

Musarò, A ;

McCullagh, K ;

Paul, A ;

Houghton, L ;

Dobrowolny, G ;

Molinaro, M ;

Barton, ER ;

Sweeney, HL ;

Rosenthal, N .

NATURE GENETICS, 2001, 27 (02) :195-200

[9]

Phelan JN, 1997, ANAT REC, V247, P179, DOI 10.1002/(SICI)1097-0185(199702)247:2<179::AID-AR4>3.0.CO

[10]

2-T