Protein microarrays as an application for disease biomarkers

被引：18

作者：

Caiazzo, Robert J., Jr. ^{[1
]}

Maher, Andrew J. ^{[1
]}

Drummond, Michael P. ^{[2
]}

Lander, Corey I. ^{[2
]}

Tassinari, Oliver W. ^{[1
]}

Nelson, Bryce P. ^{[3
]}

Liu, Brian C. -S. ^{[1
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Urol,Mol Urol Lab, Boston, MA 02115 USA

[2] Wentworth Inst Technol, Dept Comp Sci & Syst, Boston, MA USA

[3] Gentel Biosci Inc, Madison, WI USA

来源：

PROTEOMICS CLINICAL APPLICATIONS | 2009年 / 3卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Autoantibody microarrays; Bioinformatics; Forward-phase microarrays; Multiplex; Reverse-phase microarrays; CAPTURE AUTOANTIBODY MICROARRAY; HUMORAL IMMUNE-RESPONSE; PROSTATE-CANCER; OVARIAN-CANCER; ANTIBODY ARRAYS; ANTIGEN; PROGRESSION; DISCOVERY; PATHWAYS; PLATFORM;

D O I：

10.1002/prca.200800149

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein microarrays are an increasingly powerful technology in the hunt for new and novel diagnostic and prognostic biomarkers. Lending credit to the highly established DNA microarray, protein microarrays are versatile tools that utilize a variety of formats to facilitate the discovery of new biomarkers and our understanding of disease pathways. The aims of this review are: to detail a variety of protein microarray technologies currently used, including forward-phase technologies and reverse-phase technologies useful in both the discovery and validation of candidate biomarkers; to explore the strengths and weaknesses of various proteomic microarray platforms; to explain how bioinformatics helps compare data between microarray data sets; and to discuss the downstream applications of such technologies as they relate to the development of a highly personalized approach to medicine.

引用

页码：138 / 147

页数：10

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