Hypothermic responses to 8-OH-DPAT in the Ts65Dn mouse model of Down syndrome

被引:8
作者
Stasko, Melissa R.
Scott-McKean, Jonah J.
Costa, Alberto C. S.
机构
[1] Univ Denver, Eleanor Roosevelt Inst, Denver, CO 80206 USA
[2] Univ Colorado, Hlth Sci Ctr, Dept Psychiat, Denver, CO 80202 USA
关键词
Down syndrome; G-protein-activated potassium channel 2; G-protein coupled neurotransmitter receptor; 5-HTIA receptor; 5-HT7; receptor; hypothermia; 8-OH-DPAT;
D O I
10.1097/01.wnr.0000220129.78726.bb
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Recently, we have demonstrated that potassium channels containing G-protein-activated potassium channel 2 (GIRK2) subunits play a significant role in hypothermia induced by several neurotransmitter receptor agonists, including the serotonin (5-HT)IA/5-HT7 receptor agonist 8-OH-DPAT [R-(+)-8-hydroxy-2-(di-n-propyl-amino) tetralin]. The GIRK2 gene is located in human chromosome 21 (its mouse ortholog, Girk2, is in mouse chromosome 16). Down syndrome is produced by the trisomy of chromosome 21. Here, we used quantitative radiotelemetry to investigate hypothermic responses to 8-OH-DPAT in the Down syndrome mouse model Ts65Dn (which carries an extra chromosomal 16 segment containing Girk2). Our results indicate that, in relation to euploid controls, Ts65Dn mice display significantly increased hypothermic responses to 8-OH-DPAT. This finding may be relevant to the understanding of previously reported differences in serotoninergic neurotransmission in persons with Down syndrome.
引用
收藏
页码:837 / 841
页数:5
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