Synthesis of a reaction intermediate analogue of biotin-dependent carboxylases via a selective derivatization of biotin

被引：16

作者：

Amspacher, DR ^{[1
]}

Blanchard, CZ

Fronczek, FR

Saraiva, MC

Waldrop, GL

Strongin, RM

机构：

[1] Louisiana State Univ, Dept Chem, Baton Rouge, LA 70803 USA

[2] Louisiana State Univ, Dept Sci Biol, Baton Rouge, LA 70803 USA

来源：

ORGANIC LETTERS | 1999年 / 1卷 / 01期

关键词：

D O I：

10.1021/ol990026z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] An efficient and practical synthesis of 1, a unique reaction intermediate analogue of biotin dependent carboxylases, is described. The synthesis features a selective acylation of the 1'-N of biotin, Target 1 inhibits the activity of the biotin carboxylase component of acetyl CoA carboxylase. It is the first known biotin derived inhibitor of biotin carboxylase and should promote new kinetic and structural studies of the biotin dependent carboxylases.

引用

页码：99 / 102

页数：4

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