PI 3-kinases and PTEN: How opposites chemoattract

被引：110

作者：

Parent, CA

机构：

[1] NCI, Cellular & Mol Biol Lab, NIH, Bethesda, MD 20892 USA

[2] Natl Inst Gen Med Sci, PRAT Res Fellowship Program, NIH, Bethesda, MD 20892 USA

来源：

CELL | 2002年 / 109卷 / 05期

关键词：

D O I：

10.1016/S0092-8674(02)00765-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phosphatidylinositol lipids, such as PI(4,5)P-2 and PI(3,4,5)P-3, are key mediators in diverse intracellular signaling pathways. Two recent reports examine how the metabolism of these lipids by phosphatidylinositol 3-kinases and the PTEN 3-phosphoinositide phosphatase may coordinate G protein coupled signaling pathways during eukaryotic chemotaxis.

引用

页码：541 / 544

页数：4

共 20 条

[1] Signaling pathways controlling cell polarity and chemotaxis
Chung, CY
Funamoto, S
Firtel, RA
[J]. TRENDS IN BIOCHEMICAL SCIENCES, 2001, 26 (09) : 557 - 566
[2] Lipid research picks up speed on the slopes of Taos
Field, SJ
Lamia, KA
Rameh, LE
Cantley, LC
[J]. DEVELOPMENTAL CELL, 2002, 2 (04) : 407 - 410
[3] Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis
Funamoto, S
Meili, R
Lee, S
Parry, L
Firtel, RA
[J]. CELL, 2002, 109 (05) : 611 - 623
[4] Tumor suppressor PTEN mediates sensing of chemoattractant gradients
Iijima, M
Devreotes, P
[J]. CELL, 2002, 109 (05) : 599 - 610
[5] Localization of the G protein βγ complex in living cells during chemotaxis
Jin, T
Zhang, N
Long, Y
Parent, CA
Devreotes, PN
[J]. SCIENCE, 2000, 287 (5455) : 1034 - 1036
[6] Signal transduction in neutrophil chemotaxis
Katanaev, VL
[J]. BIOCHEMISTRY-MOSCOW, 2001, 66 (04) : 351 - 368
[7] PTEN: The down side of PI 3-kinase signalling
Leslie, NR
Downes, CP
[J]. CELLULAR SIGNALLING, 2002, 14 (04) : 285 - 295
[8] Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases
Liliental, J
Moon, SY
Lesche, R
Mamillapalli, R
Li, DM
Zheng, Y
Sun, H
Wu, H
[J]. CURRENT BIOLOGY, 2000, 10 (07) : 401 - 404
[9] PTEN and myotubularin: Novel phosphoinositide phosphatases
Maehama, T
Taylor, GS
Dixon, JE
[J]. ANNUAL REVIEW OF BIOCHEMISTRY, 2001, 70 : 247 - 279
[10] Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium
Meili, R
Ellsworth, C
Lee, S
Reddy, TBK
Ma, H
Firtel, RA
[J]. EMBO JOURNAL, 1999, 18 (08) : 2092 - 2105

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