Cell Death Mechanisms Induced by Cytotoxic Lymphocytes

被引:229
作者
Chavez-Galan, L. [1 ]
Arenas-Del, Angel M. C. [1 ]
Zenteno, E. [1 ]
Chavez, R. [1 ]
Lascurain, R. [1 ]
机构
[1] Univ Nacl Autonoma Mexico, Dept Bioquim, Lab 6, Fac Med, Mexico City 04510, DF, Mexico
关键词
apoptosis; cytotoxic cell; granule-dependent exocytosis; FasL; TNF; IMMUNOGLOBULIN-LIKE TRANSCRIPTS; ANTIGEN-PRESENTING CELLS; CYTOCHROME-C RELEASE; CD8(+) T-CELLS; FACTOR-KAPPA-B; GRANZYME-B; FAS LIGAND; MEDIATED APOPTOSIS; NK CELLS; CLASS-I;
D O I
10.1038/cmi.2009.3
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
One of the functions of the immune system is to recognize and destroy abnormal or infected cells to maintain homeostasis. This is accomplished by cytotoxic lymphocytes. Cytotoxicity is a highly organized multifactor process. Here, we reviewed the apoptosis pathways induced by the two main cytotoxic lymphocyte subsets, natural killer (NK) cells and CD8(+) T cells. In base to recent experimental evidence, we reviewed NK receptors involved in recognition of target-cell, as well as lytic molecules such as perforin, granzymes-A and -B, and granulysin. In addition, we reviewed the Fas-FasL intercellular linkage mediated pathway, and briefly the cross-linking of tumor necrosis factor (TNF) and TNF receptor pathway. We discussed three models of possible molecular interaction between lytic molecules from effector cytotoxic cells and target-cell membrane to induction of apoptosis. Cellular & Molecular Immunology. 2009;6(1):15-25.
引用
收藏
页码:15 / 25
页数:11
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