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Cell Death Mechanisms Induced by Cytotoxic Lymphocytes
被引:229
作者:

Chavez-Galan, L.
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机构:
Univ Nacl Autonoma Mexico, Dept Bioquim, Lab 6, Fac Med, Mexico City 04510, DF, Mexico Univ Nacl Autonoma Mexico, Dept Bioquim, Lab 6, Fac Med, Mexico City 04510, DF, Mexico

Arenas-Del, Angel M. C.
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Univ Nacl Autonoma Mexico, Dept Bioquim, Lab 6, Fac Med, Mexico City 04510, DF, Mexico Univ Nacl Autonoma Mexico, Dept Bioquim, Lab 6, Fac Med, Mexico City 04510, DF, Mexico

Zenteno, E.
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机构:
Univ Nacl Autonoma Mexico, Dept Bioquim, Lab 6, Fac Med, Mexico City 04510, DF, Mexico Univ Nacl Autonoma Mexico, Dept Bioquim, Lab 6, Fac Med, Mexico City 04510, DF, Mexico

Chavez, R.
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机构:
Univ Nacl Autonoma Mexico, Dept Bioquim, Lab 6, Fac Med, Mexico City 04510, DF, Mexico Univ Nacl Autonoma Mexico, Dept Bioquim, Lab 6, Fac Med, Mexico City 04510, DF, Mexico

Lascurain, R.
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机构:
Univ Nacl Autonoma Mexico, Dept Bioquim, Lab 6, Fac Med, Mexico City 04510, DF, Mexico Univ Nacl Autonoma Mexico, Dept Bioquim, Lab 6, Fac Med, Mexico City 04510, DF, Mexico
机构:
[1] Univ Nacl Autonoma Mexico, Dept Bioquim, Lab 6, Fac Med, Mexico City 04510, DF, Mexico
关键词:
apoptosis;
cytotoxic cell;
granule-dependent exocytosis;
FasL;
TNF;
IMMUNOGLOBULIN-LIKE TRANSCRIPTS;
ANTIGEN-PRESENTING CELLS;
CYTOCHROME-C RELEASE;
CD8(+) T-CELLS;
FACTOR-KAPPA-B;
GRANZYME-B;
FAS LIGAND;
MEDIATED APOPTOSIS;
NK CELLS;
CLASS-I;
D O I:
10.1038/cmi.2009.3
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
One of the functions of the immune system is to recognize and destroy abnormal or infected cells to maintain homeostasis. This is accomplished by cytotoxic lymphocytes. Cytotoxicity is a highly organized multifactor process. Here, we reviewed the apoptosis pathways induced by the two main cytotoxic lymphocyte subsets, natural killer (NK) cells and CD8(+) T cells. In base to recent experimental evidence, we reviewed NK receptors involved in recognition of target-cell, as well as lytic molecules such as perforin, granzymes-A and -B, and granulysin. In addition, we reviewed the Fas-FasL intercellular linkage mediated pathway, and briefly the cross-linking of tumor necrosis factor (TNF) and TNF receptor pathway. We discussed three models of possible molecular interaction between lytic molecules from effector cytotoxic cells and target-cell membrane to induction of apoptosis. Cellular & Molecular Immunology. 2009;6(1):15-25.
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页码:15 / 25
页数:11
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