Salen-Ti(OR)(4) complex catalysed trimethylsilylcyanation of aldehydes

被引:90
作者
Jiang, YZ
Gong, LZ
Feng, XM
Hu, WH
Pan, WD
Li, Z
Mi, AQ
机构
[1] Union Lab. of Asymmetric Synthesis, Chengdu Inst. of Organic Chemistry, Chinese Academy of Sciences, Chengdu
关键词
D O I
10.1016/S0040-4020(97)00984-8
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Chiral salen-titanium complexes were found to be efficient catalysts fbr the enantioselective trimethylsilylcyanation of aldehydes. An enantioselectivity up to 87.1% e.e. was obtained by using 10mol% Ti(IV)-salen 2d as catalyst. The reaction mechanism was proposed and proved experimentally. (C) 1997 Published by Elsevier Science Ltd.
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页码:14327 / 14338
页数:12
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