Modulation of NRF2 signaling pathway by nuclear receptors: Implications for cancer

被引：162

作者：

Namani, Akhileshwar ^{[1
]}

Li, Yulong ^{[1
]}

Wang, Xiu Jun ^{[2
]}

Tang, Xiuwen ^{[1
]}

机构：

[1] Zhejiang Univ, Sch Med, Dept Biochem & Genet, Hangzhou 310058, PR, Peoples R China

[2] Zhejiang Univ, Sch Med, Dept Pharmacol, Hangzhou 310058, PR, Peoples R China

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2014年 / 1843卷 / 09期

关键词：

NRF2; KEAP1; Nuclear receptor; Neh7; Cancer therapy; ANTIOXIDANT RESPONSE ELEMENT; TRANSCRIPTION FACTOR NRF2; UNION-OF-PHARMACOLOGY; CELL LUNG-CANCER; MESSENGER-RNA EXPRESSION; RETINOID-X-RECEPTORS; SMALL MAF PROTEINS; GENE-EXPRESSION; KEAP1; GENE; ERR-BETA;

D O I：

10.1016/j.bbamcr.2014.05.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Nuclear factor-erythroid 2 p45-related factor 2 (NRF2, also known as Nfe212) plays a critical role in regulating cellular defense against electrophilic and oxidative stress by activating the expression of an array of antioxidant response element-dependent genes. On one hand, NRF2 activators have been used in clinical trials for cancer prevention and the treatment of diseases associated with oxidative stress; on the other hand, constitutive activation of NRF2 in many types of tumors contributes to the survival and growth of cancer cells, as well as resistance to anticancer therapy. In this review, we provide an overview of the NRF2 signaling pathway and discuss its role in carcinogenesis. We also introduce the inhibition of NRF2 by nuclear receptors. Further, we address the biological significance of regulation of the NRF2 signaling pathway by nuclear receptors in health and disease. Finally, we discuss the possible impact of NRF2 inhibition by nuclear receptors on cancer therapy. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：1875 / 1885

页数：11

共 158 条

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