Enzymes in organic chemistry .5. First and chemo-enzymatic synthesis of alpha-aminooxyphosphonic acids of high enantiomeric excess

被引：26

作者：

Drescher, M ^{[1
]}

Hammerschmidt, F ^{[1
]}

机构：

[1] UNIV VIENNA,INST ORGAN CHEM,A-1090 VIENNA,AUSTRIA

来源：

TETRAHEDRON | 1997年 / 53卷 / 13期

关键词：

ENANTIOSELECTIVE HYDROLYSIS; ABSOLUTE-CONFIGURATION; ASYMMETRIC-SYNTHESIS; PHENYLALANINE; ANALOGS; PHOSPHONATES; DERIVATIVES; INHIBITORS; REDUCTION; ESTERS;

D O I：

10.1016/S0040-4020(97)00174-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

alpha-Acyloxyphosphonates (+/-)-5a and (+/-)-5b, derived from 3-phenylpropionaldehyde and acetaldehyde. were involved by lipase-catalyzed enantioselective hydrolysis. Three of the four chiral, non-racemic alpha-hydroxyphosphonates obtained had 99% ee. the fourth 91%. They were transformed chemically into alpha-aminooxyphosphonic acids. (C) 1997 Elsevier Science Ltd.

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收藏

页码：4627 / 4636

页数：10

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