Self-energy-limited ion transport in subnanometer channels

被引：59

作者：

Bonthuis, Douwe Jan ^{[1
]}

Zhang, Jingshan

Hornblower, Breton

Mathe, Jerome

Shklovskii, Boris I.

Meller, Amit

机构：

[1] Boston Univ, Dept Phys, Boston, MA 02215 USA

[2] Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA

[3] Univ Minnesota, William I Fine Theoret Phys Inst, Minneapolis, MN USA

[4] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95060 USA

来源：

PHYSICAL REVIEW LETTERS | 2006年 / 97卷 / 12期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1103/PhysRevLett.97.128104

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

The current-voltage characteristics of the alpha-Hemolysin protein pore during the passage of single-stranded DNA under varying ionic strength C are studied experimentally. We observe strong blockage of the current, weak superlinear growth of the current as a function of voltage, and a minimum of the current as a function of C. These observations are interpreted as the result of the ion electrostatic self-energy barrier originating from the large difference in the dielectric constants of water and the lipid bilayer. The dependence of DNA capture rate on C also agrees with our model.

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页数：4

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