Baseline Ad5 serostatus does not predict Ad5 HIV vaccine-induced expansion of adenovirus-specific CD4+ T cells

被引：79

作者：

Hutnick, Natalie A. ^{[1
,2
]}

Carnathan, Diane G. ^{[1
,2
]}

Dubey, Sheri A. ^{[3
]}

Cox, Kara S. ^{[3
]}

Kierstead, Lisa ^{[3
]}

Ratcliffe, Sarah J. ^{[4
]}

Robertson, Michael N. ^{[3
]}

Casimiro, Danilo R. ^{[3
]}

Ertl, Hildegund C. J. ^{[5
]}

Betts, Michael R. ^{[1
,2
]}

机构：

[1] Univ Penn, Sch Med, Dept Microbiol, Philadelphia, PA 19104 USA

[2] Univ Penn, Sch Med, Ctr AIDS Res, Philadelphia, PA 19104 USA

[3] Merck Res Labs, West Point, PA USA

[4] Univ Penn, Sch Med, Dept Epidemiol & Biostat, Philadelphia, PA 19104 USA

[5] Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA

来源：

NATURE MEDICINE | 2009年 / 15卷 / 08期

基金：

美国国家卫生研究院;

关键词：

STEP; IMMUNITY; TYPE-5; GENE;

D O I：

10.1038/nm.1989

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The mechanisms underlying possible increased HIV-1 acquisition in adenovirus 5 (Ad5)-seropositive subjects vaccinated with Ad5-HIV-1 vectors in the Merck STEP trial remain unclear. We find that Ad5 serostatus does not predict Ad5-specific CD4(+) T cell frequency, and we did not observe durable significant differences in Ad5-specific CD4(+) T cells between Ad5-seropositive and Ad5-seronegative subjects after vaccination. These findings indicate no causative role for Ad5-specific CD4(+) T cells in increasing HIV-1 susceptibility in the STEP trial. (C) 2009 Nature America, Inc. All rights reserved.

引用

页码：876 / 878

页数：3

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