Where to begin? The mechanism of translation initiation codon selection in eukaryotes

被引：22

作者：

Algire, Mikkel A. ^{[1
]}

Lorsch, Jon R. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Biophys & Biophys Chem, Baltimore, MD 21205 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2006年 / 10卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.cbpa.2006.08.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Selecting the codon at which to begin translation is a complicated event in an already complicated process. Many protein initiation factors (elFs) have been implicated in start site selection, but the mechanistic details of their activities have remained obscure until recently. Biochemical and genetic studies of elFs 1, 1A, 2 and 5 have suggested that the 43S pre-initiation complex exists in two conformations and that the changing interactions of the factors within the 43S pre-initiation complex in response to encountering an AUG codon regulates these conformations and, ultimately, the selection of the start codon.

引用

页码：480 / 486

页数：7

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