The interferon-induced gene ISG12 is regulated by various cytokines as the gene 6-16 in human cell lines

被引：44

作者：

Gjermandsen, IM ^{[1
]}

Justesen, J ^{[1
]}

Martensen, PM ^{[1
]}

机构：

[1] Aarhus Univ, Dept Biol Mol & Struct, DK-8000 Aarhus C, Denmark

来源：

CYTOKINE | 2000年 / 12卷 / 03期

关键词：

6-16; interferon; ISG12; p27; poly(I)-poly(C); RT-PCR;

D O I：

10.1006/cyto.1999.0549

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The gene for ISG12 (originally designated p27) was isolated as an oestrogen-induced gene. The authors undertook a comprehensive study using quantitative RT-PCR, in which we delineate the regulation of ISG12 by seven different cytokines including interferons and poly(I). poly(C) in seven human cell lines of different origin. In all cell lines ISG12 is strongly induced by IFN-alpha and only slightly by TFN gamma. Poly(I). poly(C) induces ISG12 in a cell line-dependent manner, whereas none of the other cytokines tested elicited a response. Comparing the induction pattern of ISG12 to that of 6-16 a high degree of similarity was found. The induction levels varied, however, between cell lines. (C) 2000 Academic Press.

引用

页码：233 / 238

页数：6

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