CD156 (human ADAM8): Expression, primary amino acid sequence, and gene location

被引：93

作者：

Yoshiyama, K ^{[1
]}

Higuchi, Y ^{[1
]}

Kataoka, M ^{[1
]}

Matsuura, K ^{[1
]}

Yamamoto, S ^{[1
]}

机构：

[1] OITA MED UNIV,DEPT PATHOL,HASAMA,OITA 87955,JAPAN

来源：

GENOMICS | 1997年 / 41卷 / 01期

关键词：

D O I：

10.1006/geno.1997.4607

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The murine cell-surface antigen MS2 [ADAM 8; mouse CD156 (mCD156)] is a transmembrane glycoprotein that is highly expressed in monocytic lineages. mCD156 consists of a long exterior region containing domains strikingly similar to those of hemorrhagic snake venom proteins. cDNA for human CD156 was isolated from cDNA libraries from the human macrophage cell line THP-1 and from human granulocytes. The CD156 cDNA detected mRNA from human macrophage cell lines, granulocytes, monocytes, and B cell but not T cell lines, The nucleotide sequence of the CD156 cDNA showed 65.6% homology with that of mCD156, and its amino acid sequence had high homology with hemorrhagic snake venom proteins and other related mammalian proteins, The CD156 gene was mapped to human chromosome 10q26.3. (C) 1996 Academic Press.

引用

页码：56 / 62

页数：7

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