The role of T-cell receptor dimerization in T-cell activation

被引：39

作者：

Bachmann, MF

Ohashi, PS

机构：

[1] Basel Inst Immunol, CH-4005 Basel, Switzerland

[2] Ontario Canc Inst, Dept Med Biophys, Toronto, ON M5G 2M9, Canada

[3] Ontario Canc Inst, Dept Immunol, Toronto, ON M5G 2M9, Canada

来源：

IMMUNOLOGY TODAY | 1999年 / 20卷 / 12期

关键词：

D O I：

10.1016/S0167-5699(99)01543-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T-cell specificity is encoded in single T-cell receptors (TCRs) but monovalent interactions with peptide bound to the major histocompatibility complex (MHC) may not sufficiently account for the complexities associated with T-cell activation. This review proposes that TCRs undergo dimerization before activation and that this property might be essential for both T-cell antagonism and T-cell specificity, and may be pivotal for T-cell survival versus T-cel activation.

引用

页码：568 / 575

页数：8

共 81 条

[1] DIMERIZATION OF SOLUBLE MAJOR HISTOCOMPATIBILITY COMPLEX PEPTIDE COMPLEXES IS SUFFICIENT FOR ACTIVATION OF T-CELL HYBRIDOMA AND INDUCTION OF UNRESPONSIVENESS [J].