Isolation of lignans and sesquiterpenoids from leaves of Zanthoxylum naranjillo

From the hexane crude extract of the leaves of Zanthoxylum naranjillo, fourteen compounds were isolated. Three sesquiterpenes: beta-selinene, alpha-cyperone and (-)-juniper camphor; four furofuran lignans: (+)-sesamin, (-)-pluviatylol-4'-O-gamma,gamma-dimethylallyl ether, (-)-xanthoxylol-4'-O-gamma,gamma-dimethylallyl ether, (+)-piperitol-4'O-gamma,gamma-dimethylallyl ether; four dibenzylbutyrolactone lignans: (-)-hinokinin, (-)-hibalactone, (-)-methylpluviatolide, (-)-kaerophylin; two furan lignans: (-)-cubebin and (-)-3,4-dimethoxy-3,4-desmethylenedioxycubebin. Sitosterol was also present. These compounds were isolated for the first time from Z. naranjillo.