Regional cerebral glucose metabolism in dementia with Lewy bodies and Alzheimer's disease: a comparative study using positron emission tomography

被引：111

作者：

Imamura, T ^{[1
]}

Ishii, K ^{[1
]}

Sasaki, M ^{[1
]}

Kitagaki, H ^{[1
]}

Yamaji, S ^{[1
]}

Hirono, N ^{[1
]}

Shimomura, T ^{[1
]}

Hashimoto, M ^{[1
]}

Tanimukai, S ^{[1
]}

Kazui, H ^{[1
]}

Mori, E ^{[1
]}

机构：

[1] HYOGO INST AGING BRAIN & COGNIT DISORDERS,DIV NEUROIMAGING RES,HIMEJI,HYOGO 670,JAPAN

来源：

NEUROSCIENCE LETTERS | 1997年 / 235卷 / 1-2期

关键词：

dementia with Lewy bodies; Alzheimer's disease; positron emission tomography; F-18]fluorodeoxyglucose; occipital lobe; cerebellum; limbic area;

D O I：

10.1016/S0304-3940(97)00713-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Regional cerebral metabolic rate of glucose (rCMRglc) was studied in 19 patients with a clinical diagnosis of dementia with Lewy bodies (DLB) and 19 patients with a clinical diagnosis of Alzheimer's disease (AD), using [F-18]fluorodeoxyglucose ([F-18]FDG) and positron emission tomography (PET). The two groups were matched with age, gender, disease duration and severity of cognitive disturbances. In 'dementia with Lewy bodies' (DLB) patients, when compared with AD patients, significant rCMRglc decreases were distributed in the temporo-parieto-occipital association cortices and the cerebellar hemispheres. In contrast, the medial temporal and cingulate rCMRglc were significantly lower in AD patients than those in DLB patients. These different regional emphases of glucose hypometabolism are consistent with the pathological and neurochemical differences between DLB and AD and explain the different clinical features of the two diseases. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：49 / 52

页数：4

共 24 条

[1] Fluoro-deoxyglucose positron emission tomography in diffuse Lewy body disease [J].

Albin, RL ;

Minoshima, S ;

DAmato, CJ ;

Frey, KA ;

Kuhl, DA ;

Sima, AAF .

NEUROLOGY, 1996, 47 (02) :462-466

[2] MINI-MENTAL STATE - PRACTICAL METHOD FOR GRADING COGNITIVE STATE OF PATIENTS FOR CLINICIAN [J].

FOLSTEIN, MF ;

FOLSTEIN, SE ;

MCHUGH, PR .

JOURNAL OF PSYCHIATRIC RESEARCH, 1975, 12 (03) :189-198

[3] THE LEWY-BODY VARIANT OF ALZHEIMERS-DISEASE - CLINICAL AND PATHOLOGICAL FINDINGS [J].

FORSTL, H ;

BURNS, A ;

LUTHERT, P ;

CAIRNS, N ;

LEVY, R .

BRITISH JOURNAL OF PSYCHIATRY, 1993, 162 :385-392

[4]

Friston Holmes, 1994, Human Brain Mapping, V2, P189, DOI [10.1002/hbm.460020402, DOI 10.1002/HBM.460020402]

[5] Clock-face drawing to differentiate Lewy body and Alzheimer type dementia syndromes [J].

Gnanalingham, KK ;

Byrne, EJ ;

Thornton, A .

LANCET, 1996, 347 (9002) :696-697

[6] POSITRON EMISSION TOMOGRAPHIC (PET) STUDIES IN DEMENTIA [J].

GOTO, I ;

TANIWAKI, T ;

HOSOKAWA, S ;

OTSUKA, M ;

ICHIYA, Y ;

ICHIMIYA, A .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1993, 114 (01) :1-6

[7]

HANSEN L, 1990, NEUROLOGY, V40, P1

[8]

Ishii K, 1997, J NUCL MED, V38, P925

[9] DIFFUSE LEWY BODY DISEASE IN JAPAN [J].

KOSAKA, K .

JOURNAL OF NEUROLOGY, 1990, 237 (03) :197-204

[10] NEUROTRANSMITTERS IN BASAL GANGLIA AND CORTEX OF ALZHEIMERS-DISEASE WITH AND WITHOUT LEWY BODIES [J].

LANGLAIS, PJ ;

THAL, L ;

HANSEN, L ;

GALASKO, D ;

ALFORD, M ;

MASLIAH, E .

NEUROLOGY, 1993, 43 (10) :1927-1934

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