Decreased GDNF mRNA expression in dorsal spinal cord of unilateral arthritic rat

被引：10

作者：

Fang, M ^{[1
]}

Wang, Y ^{[1
]}

Liu, HX ^{[1
]}

Liu, XS ^{[1
]}

Han, JS ^{[1
]}

机构：

[1] Beijing Med Univ, Neurosci Res Inst, Beijing 100083, Peoples R China

来源：

NEUROREPORT | 2000年 / 11卷 / 04期

关键词：

arthritis; chronic pain; GDNF; neurotrophin; rat; spinal cord;

D O I：

10.1097/00001756-200003200-00017

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

It is now well established that nerve growth factor (NGF) plays a key role in inflammation-induced hyperalgesia. It was also reported that brain derived neurotrophic factor (BDNF), another member of neurotrophins, contributed to the pain pathway as a neurotransmitter in the CNS. The present work demonstrated a down-regulation of glial cell line-derived neurotrophic factor (GDNF) mRNA expression in dorsal spinal cord in complete Freund's adjuvant-induced unilateral arthritic rats serving as a chronic pain model. The fast occurring and long lasting down-regulations suggest that GDNF might contribute to pain pathway in a way different from neurotrophins and might play a role in the maintenance of chronic pain status. NeuroReport 11:737-741 (C) 2000 Lippincott Williams & Wilkins.

引用

页码：737 / 741

页数：5

共 13 条

[1]

Bennett DLH, 1998, J NEUROSCI, V18, P3059

[2] Primary afferent tachykinins are required to experience moderate to intense pain [J].

Cao, YQ ;

Mantyh, PW ;

Carlson, EJ ;

Gillespie, AM ;

Epstein, CJH ;

Basbaum, AI .

NATURE, 1998, 392 (6674) :390-394

[3] The neurobiology of pain [J].

Dubner, R ;

Gold, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (14) :7627-7630

[4] Immunocytochemical localization of GDNF in primary afferents of the lumbar dorsal horn [J].

Holstege, JC ;

Jongen, JLM ;

Kennis, JHH ;

van Rooyen-Boot, AAMA ;

Vecht, CJ .

NEUROREPORT, 1998, 9 (12) :2893-2897

[5] Depletion of GDNF from primary afferents in adult rat dorsal horn following peripheral axotomy [J].

Jongen, JLM ;

Dalm, E ;

Vecht, CJ ;

Holstege, JC .

NEUROREPORT, 1999, 10 (04) :867-871

[6]

Liu HX, 1998, CHINESE J PAIN MED, V4, P173

[7] Neurotrophins: Peripherally and centrally acting modulators of tactile stimulus-induced inflammatory pain hypersensitivity [J].

Mannion, RJ ;

Costigan, M ;

Decosterd, I ;

Amaya, F ;

Ma, QP ;

Holstege, JC ;

Ji, RR ;

Acheson, A ;

Lindsay, RM ;

Wilkinson, GA ;

Woolf, CJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (16) :9385-9390

[8]

Mendell LM, 1999, MICROSC RES TECHNIQ, V45, P252, DOI 10.1002/(SICI)1097-0029(19990515/01)45:4/5<252::AID-JEMT9>3.0.CO

[9]

2-N

[10] Glial cell line derived neurotrophic factor (GDNF) regulates VR1 and substance P in cultured sensory neurons [J].

Ogun-Muyiwa, P ;

Helliwell, R ;

McIntyre, P ;

Winter, J .

NEUROREPORT, 1999, 10 (10) :2107-2111

← 1 2 →