Decreased GDNF mRNA expression in dorsal spinal cord of unilateral arthritic rat

被引：10

作者：

Fang, M ^{[1
]}

Wang, Y ^{[1
]}

Liu, HX ^{[1
]}

Liu, XS ^{[1
]}

Han, JS ^{[1
]}

机构：

[1] Beijing Med Univ, Neurosci Res Inst, Beijing 100083, Peoples R China

来源：

NEUROREPORT | 2000年 / 11卷 / 04期

关键词：

arthritis; chronic pain; GDNF; neurotrophin; rat; spinal cord;

D O I：

10.1097/00001756-200003200-00017

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

It is now well established that nerve growth factor (NGF) plays a key role in inflammation-induced hyperalgesia. It was also reported that brain derived neurotrophic factor (BDNF), another member of neurotrophins, contributed to the pain pathway as a neurotransmitter in the CNS. The present work demonstrated a down-regulation of glial cell line-derived neurotrophic factor (GDNF) mRNA expression in dorsal spinal cord in complete Freund's adjuvant-induced unilateral arthritic rats serving as a chronic pain model. The fast occurring and long lasting down-regulations suggest that GDNF might contribute to pain pathway in a way different from neurotrophins and might play a role in the maintenance of chronic pain status. NeuroReport 11:737-741 (C) 2000 Lippincott Williams & Wilkins.

引用

页码：737 / 741

页数：5

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