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Schizophrenia: a purinergic hypothesis

被引：83
作者：
Lara, DR [1 ]
Souza, DO [1 ]
机构：
[1] Univ Fed Rio Grande do Sul, Dept Bioquim, ICBS, BR-90035003 Porto Alegre, RS, Brazil
来源：
MEDICAL HYPOTHESES | 2000年 / 54卷 / 02期
关键词：
D O I：
10.1054/mehy.1999.0003
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Knowledge of the physiological roles of the purinergic system and its influence on other neurotransmitter systems has greatly advanced. In this article, a purinergic model is proposed as an attempt to integrate several findings in schizophrenia. According to this hypothesis, a purinergic system dysfunction would mainly result in reduced adenosinergic activity. This model also addresses the systemic aspects of schizophrenia, based on peripheral roles of purines, such as modulation of the immune system. (C) 2000 Harcourt Publishers Ltd.
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页码：157 / 166
页数：10
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