Practical synthesis of chiral ligands for catalytic enantioselective cyanosilylation of ketones and ketoimines

被引：33

作者：

Kato, N ^{[1
]}

Tomita, D ^{[1
]}

Maki, K ^{[1
]}

Kanai, M ^{[1
]}

Shibasaki, M ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2004年 / 69卷 / 18期

关键词：

D O I：

10.1021/jo049258o

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical synthesis of chiral ligands that are useful for catalytic enantioselective cyanosilylation of ketones and ketoimines is described. Compared with the previous synthetic route, the number of total steps is decreased and the total yield is greatly improved. Furthermore, both (+)- and (-)-ligands are readily available by this new synthetic route.

引用

页码：6128 / 6130

页数：3

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