Iron loading: a risk factor for osteoporosis

被引：186

作者：

Weinberg, E. D. ^{[1
]}

机构：

[1] Indiana Univ, Dept Biol, Bloomington, IN 47405 USA

[2] Indiana Univ, Med Sci Program, Bloomington, IN 47405 USA

来源：

BIOMETALS | 2006年 / 19卷 / 06期

关键词：

African siderosis; hemochromatosis; HIV infection; iron loading; lactoferrin; osteoblasts; osteoclasts; osteoporosis; sickle cell anemia; tea catechins; thalassemia;

D O I：

10.1007/s10534-006-9000-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Iron loaded persons are at increased risk for infection, neoplasia, arthropathy, cardiomyopathy and an array of endocrine and neurodegenerative diseases. This report summarizes evidence of increased risk of iron loading for osteoporosis. Iron suppresses bone remodeling apparently by decreasing osteoblast formation and new bone synthesis. Low molecular mass iron chelators as well as a natural protein iron chelator, lactoferrin, may be useful in prevention of osteoporosis.

引用

收藏

页码：633 / 635

页数：3

相关论文

共 14 条

[1]

Osteoporosis in HFE2 juvenile hemochromatosis. A case report and review of the literature [J].

Angelopoulos, NG ;

Goula, AK ;

Papanikolaou, G ;

Tolis, G .

OSTEOPOROSIS INTERNATIONAL, 2006, 17 (01) :150-155

[2]

Patterns of bone diseases in transfusion-dependent homozygous thalassaemia major: predominance of osteoporosis and desferrioxamine-induced bone dysplasia [J].

Chan, YL ;

Pang, LM ;

Chik, KW ;

Cheng, JCY ;

Li, CK .

PEDIATRIC RADIOLOGY, 2002, 32 (07) :492-497

[3]

Green tea catechin enhances osteogenesis in a bone marrow mesenchymal stem cell line [J].

Chen, CH ;

Ho, ML ;

Chang, JK ;

Hung, SH ;

Wang, GJ .

OSTEOPOROSIS INTERNATIONAL, 2005, 16 (12) :2039-2045

[4]

Lactoferrin is a potent regulator of bone cell activity and increases bone. formation in vivo [J].

Cornish, J ;

Callon, KE ;

Naot, D ;

Palmano, KP ;

Banovic, T ;

Bava, U ;

Watson, M ;

Lin, JM ;

Tong, PC ;

Chen, Q ;

Chan, VA ;

Reid, HE ;

Fazzalari, N ;

Baker, HM ;

Baker, EN ;

Haggarty, NW ;

Grey, AB ;

Reid, IR .

ENDOCRINOLOGY, 2004, 145 (09) :4366-4374

[5]

DEVERNEJOUL MC, 1984, AM J PATHOL, V116, P377

[6]

FAUSTO A, 2006, IN PRESS BONE, V38

[7]

Bone mineral density in men with genetic hemochromatosis and HFE gene mutation [J].

Guggenbuhl, P ;

Deugnier, Y ;

Boisdet, JF ;

Rolland, Y ;

Perdriger, A ;

Pawlotsky, Y ;

Chalès, G .

OSTEOPOROSIS INTERNATIONAL, 2005, 16 (12) :1809-1814

[8]

Lactoferrin reduces in vitro osteoclast differentiation and resorbing activity [J].

Lorget, F ;

Clough, J ;

Oliveira, M ;

Daury, MC ;

Sabokbar, A ;

Offord, E .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2002, 296 (02) :261-266

[9]

Rollot F, 2005, J RHEUMATOL, V32, P376

[10]

Ascorbic acid deficiency, iron overload and alcohol abuse underlie the severe osteoporosis in black African patients with hip fractures - A bone histomorphometric study [J].

Schnitzler, CM ;

Schnaid, E ;

MacPhail, AP ;

Mesquita, JM ;

Robson, HJ .

CALCIFIED TISSUE INTERNATIONAL, 2005, 76 (02) :79-89