Detection and manipulation of biomolecules by magnetic carriers

被引：72

作者：

Brzeska, M

Panhorst, M

Kamp, PB

Schotter, J

Reiss, G

Pühler, A

Becker, A

Brückl, H

机构：

[1] Univ Bielefeld, Dept Phys, D-33615 Bielefeld, Germany

[2] Univ Bielefeld, Dept Genet, D-33615 Bielefeld, Germany

来源：

JOURNAL OF BIOTECHNOLOGY | 2004年 / 112卷 / 1-2期

关键词：

molecular recognition; biochip; marker; sensor; magnetoresistive; bonding force;

D O I：

10.1016/j.jbiotec.2004.04.018

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The detection and manipulation of single molecules on a common platform would be of great interest for basic research of biological or chemical systems. A promising approach is the application of magnetic carriers. The principles are demonstrated in this contribution. It is shown that paramagnetic beads can be detected by highly sensitive magnetoresistive sensors yielding a purely electronic signal. Different configurations are discussed. The capability of the sensors to detect even single markers is demonstrated by a model experiment. In addition, the paramagnetic beads can be used as carriers for biomolecules. They can be manipulated on-chip via currents running through specially designed line patterns. Thus, magnetic markers in combination with magnetoresistive sensors are a promising choice for future integrated lab-on-a-chip systems. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：25 / 33

页数：9

共 15 条

[1] GIANT MAGNETORESISTANCE OF (001)FE/(001) CR MAGNETIC SUPERLATTICES [J].