Alzheimer transgenic mouse models come of age

[1] Familial Alzheimer's disease-linked presenilin 1 variants elevate A beta 1-42/1-40 ratio in vitro and in vivo [J]. NEURON, 1996, 17 (05) : 1005 - 1013

[2] Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice [J]. NATURE MEDICINE, 1997, 3 (01) : 67 - 72

[3] Increased amyloid-beta 42(43) in brains of mice expressing mutant presenilin 1 [J]. NATURE, 1996, 383 (6602) : 710 - 713

[4] ALZHEIMER-TYPE NEUROPATHOLOGY IN TRANSGENIC MICE OVEREXPRESSING V717F BETA-AMYLOID PRECURSOR PROTEIN [J]. NATURE, 1995, 373 (6514) : 523 - 527

[5] Correlative memory deficits, A beta elevation, and amyloid plaques in transgenic mice [J]. SCIENCE, 1996, 274 (5284) : 99 - 102

[6] AGE-RELATED CNS DISORDER AND EARLY DEATH IN TRANSGENIC FVB/N MICE OVEREXPRESSING ALZHEIMER AMYLOID PRECURSOR PROTEINS [J]. NEURON, 1995, 15 (05) : 1203 - 1218

[7] JOHNSONWOOD K, IN PRESS P NATL ACAD

[8] Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease [J]. NATURE MEDICINE, 1996, 2 (08) : 864 - 870

[9] Sommer B., 1996, Society for Neuroscience Abstracts, V22, P25

[10] Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo [J]. NEURON, 1996, 17 (01) : 181 - 190

[1] Familial Alzheimer's disease-linked presenilin 1 variants elevate A beta 1-42/1-40 ratio in vitro and in vivo [J]. NEURON, 1996, 17 (05) : 1005 - 1013

[2] Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice [J]. NATURE MEDICINE, 1997, 3 (01) : 67 - 72

[3] Increased amyloid-beta 42(43) in brains of mice expressing mutant presenilin 1 [J]. NATURE, 1996, 383 (6602) : 710 - 713

[4] ALZHEIMER-TYPE NEUROPATHOLOGY IN TRANSGENIC MICE OVEREXPRESSING V717F BETA-AMYLOID PRECURSOR PROTEIN [J]. NATURE, 1995, 373 (6514) : 523 - 527

[5] Correlative memory deficits, A beta elevation, and amyloid plaques in transgenic mice [J]. SCIENCE, 1996, 274 (5284) : 99 - 102

[6] AGE-RELATED CNS DISORDER AND EARLY DEATH IN TRANSGENIC FVB/N MICE OVEREXPRESSING ALZHEIMER AMYLOID PRECURSOR PROTEINS [J]. NEURON, 1995, 15 (05) : 1203 - 1218

[7] JOHNSONWOOD K, IN PRESS P NATL ACAD

[8] Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease [J]. NATURE MEDICINE, 1996, 2 (08) : 864 - 870

[9] Sommer B., 1996, Society for Neuroscience Abstracts, V22, P25

[10] Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo [J]. NEURON, 1996, 17 (01) : 181 - 190