Mouse plasmacytoid dendritic cells derive exclusively from estrogen-resistant myeloid progenitors

被引：37

作者：

Harman, Benjamin C.

Miller, Juli P.

Nikbakht, Neda

Gerstein, Rachel

Allman, David

机构：

[1] Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

[2] Univ Massachusetts, Sch Med, Dept Mol Genet & Microbiol, Worcester, MA 01605 USA

来源：

BLOOD | 2006年 / 108卷 / 03期

关键词：

D O I：

10.1182/blood-2005-11-4545

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Current models predict that mouse plasmacytoid dendritic cells (PDCs) derive from lymphoid progenitors. However, we show PDCs arise exclusively from common myeloid progenitors (CMPs) characterized by low-level expression of several lymphoid-associated genes, including a RAG2/GFP reporter transgene. This conclusion is supported by both adoptive transfer experiments and an estrogen treatment strategy that led to marked depletion of very early lymphoid progenitors without affecting RAG2/GFP(+) CMPs or the developmental kinetics, RAG-mediated recombinase activity, and cytokine production of PDCs. These data suggest that IPDCs arise exclusively from early myeloid progenitors and that promiscuous low-level expression of lymphoidassociated genes is a general feature of PDC progenitors among CMPs.

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收藏

页码：878 / 885

页数：8

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共 47 条

[1] Upregulation of flt3 expression within the bone marrow Lin-Sca1+c-kit+ stem cell compartment is accompanied by loss of self-renewal capacity [J].

Adolfsson, J ;

Borge, OJ ;

Bryder, D ;

Theilgaard-Mönch, K ;

Åstrand-Grundström, I ;

Sitnicka, E ;

Sasaki, Y ;

Jacobsen, SEW .

IMMUNITY, 2001, 15 (04) :659-669

[2] Cytokines and transcription factors that regulate T helper cell differentiation: New players and new insights [J].

Agnello, D ;

Lankford, CSR ;

Bream, J ;

Morinobu, A ;

Gadina, M ;

O'Shea, JJ ;

Frucht, DM .

JOURNAL OF CLINICAL IMMUNOLOGY, 2003, 23 (03) :147-161

[3] A clonogenic common myeloid progenitor that gives rise to all myeloid lineages [J].

Akashi, K ;

Traver, D ;

Miyamoto, T ;

Weissman, IL .

NATURE, 2000, 404 (6774) :193-197

[4] Thymopoiesis independent of common lymphoid progenitors [J].

Allman, D ;

Sambandam, A ;

Kim, S ;

Miller, JP ;

Pagan, A ;

Well, D ;

Meraz, A ;

Bhandoola, A .

NATURE IMMUNOLOGY, 2003, 4 (02) :168-174

[5] Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation [J].

Allman, D ;

Lindsley, RC ;

DeMuth, W ;

Rudd, K ;

Shinton, SA ;

Hardy, RR .

JOURNAL OF IMMUNOLOGY, 2001, 167 (12) :6834-6840

[6] Mouse type IIFN-producing cells are immature APCs with plasmacytoid morphology [J].

Asselin-Paturel, C ;

Boonstra, A ;

Dalod, M ;

Durand, I ;

Yessaad, N ;

Dezutter-Dambuyant, C ;

Vicari, A ;

O'Garra, A ;

Biron, C ;

Brière, F ;

Trinchieri, G .

NATURE IMMUNOLOGY, 2001, 2 (12) :1144-1150

[7] Frontline:: A B220+ CD117+ CD19- hematopoietic progenitor with potent lymphoid and myeloid developmental potential [J].

Balciunaite, G ;

Ceredig, R ;

Massa, S ;

Rolink, AG .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2005, 35 (07) :2019-2030

[8] Isolation and characterization of plasmacytoid dendritic cells from Flt3 ligand and granulocyte-macrophage colony-stimulating factor-treated mice [J].

Björck, P .

BLOOD, 2001, 98 (13) :3520-3526

[9] B lineage-specific regulation of V(D)J recombinase activity is established in common lymphoid progenitors [J].

Borghesi, L ;

Hsu, LY ;

Miller, JP ;

Anderson, M ;

Herzenberg, L ;

Herzenberg, L ;

Schlissel, MS ;

Allman, D ;

Gerstein, RM .

JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 199 (04) :491-502

[10] Clonal type I interferon-producing and dendritic cell precursors are contained in both human lymphoid and myeloid progenitor populations [J].

Chicha, L ;

Jarrossay, D ;

Manz, MG .

JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 200 (11) :1519-1524

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