Small cell lung cancer: the importance of the extracellular matrix

被引：46

作者：

Buttery, RC ^{[1
]}

Rintoul, RC ^{[1
]}

Sethi, T ^{[1
]}

机构：

[1] Univ Edinburgh, Rayne Lab, Ctr Inflammat Res, Edinburgh EH8 9AG, Midlothian, Scotland

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2004年 / 36卷 / 07期

关键词：

chemotherapy; extracellular matrix; lung cancer;

D O I：

10.1016/S1357-2725(03)00261-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lung cancer is the leading cause of cancer deaths in the UK and the small cell lung cancer (SCLC) phenotype is the most aggressive form of this disease, with a high metastatic potential and the development of resistance to chemotherapy. Evidence now suggests that these features may be due to important links between the cancer cells and proteins in their local extracellular matrix (ECM). This article reviews the evidence for a chemoprotective effect of extracellular matrix in small cell lung cancer and discusses the importance of integrin-mediated signalling pathways in this setting. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：1154 / 1160

页数：7

共 29 条

[1] Matrix metalloproteinases and matrix metalloproteinase inhibitors in lung cancer
Bonomi, P
[J]. SEMINARS IN ONCOLOGY, 2002, 29 (01) : 78 - 86
[2] SUPPRESSION OF ICE AND APOPTOSIS IN MAMMARY EPITHELIAL-CELLS BY EXTRACELLULAR-MATRIX
BOUDREAU, N
SYMPSON, CJ
WERB, Z
BISSELL, MJ
[J]. SCIENCE, 1995, 267 (5199) : 891 - 893
[3] A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer
Bramhall, SR
Schulz, J
Nemunaitis, J
Brown, PD
Baillet, M
Buckels, JAC
[J]. BRITISH JOURNAL OF CANCER, 2002, 87 (02) : 161 - 167
[4] Brognard J, 2001, CANCER RES, V61, P3986
[5] Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinase
Chen, HC
Appeddu, PA
Isoda, H
Guan, JL
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (42) : 26329 - 26334
[6] EXPRESSION OF BETA-1, BETA-3, BETA-4, AND BETA-5 INTEGRINS BY HUMAN LUNG-CARCINOMA CELLS OF DIFFERENT HISTOTYPES
FALCIONI, R
CIMINO, L
GENTILESCHI, MP
DAGNANO, I
ZUPI, G
KENNEL, SJ
SACCHI, A
[J]. EXPERIMENTAL CELL RESEARCH, 1994, 210 (01) : 113 - 122
[7] RECONSTITUTED BASEMENT-MEMBRANE (MATRIGEL) AND LAMININ CAN ENHANCE THE TUMORIGENICITY AND THE DRUG-RESISTANCE OF SMALL-CELL LUNG-CANCER CELL-LINES
FRIDMAN, R
GIACCONE, G
KANEMOTO, T
MARTIN, GR
GAZDAR, AF
MULSHINE, JL
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (17) : 6698 - 6702
[8] Apoptosis and the dilemma of cancer chemotherapy
Hannun, YA
[J]. BLOOD, 1997, 89 (06) : 1845 - 1853
[9] Adhesion to fibronectin via β1 integrins regulates p27kip1 levels and contributes to cell adhesion mediated drug resistance (CAM-DR)
Hazlehurst, LA
Damiano, JS
Buyuksal, I
Pledger, WJ
Dalton, WS
[J]. ONCOGENE, 2000, 19 (38) : 4319 - 4327
[10] INTEGRIN EXPRESSION AND ABILITY TO ADHERE TO EXTRACELLULAR-MATRIX PROTEINS AND ENDOTHELIAL-CELLS IN HUMAN LUNG-CANCER LINES
HIRASAWA, M
SHIJUBO, N
UEDE, T
ABE, S
[J]. BRITISH JOURNAL OF CANCER, 1994, 70 (03) : 466 - 473

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