Effects of chronic fenfluramine administration on hypothalamic neuropeptide mRNA expression

被引：30

作者：

Choi, S

Blake, V

Cole, S

Fernstrom, JD

机构：

[1] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA 15213 USA

[2] Univ Pittsburgh, Sch Med, Dept Psychol, Pittsburgh, PA 15213 USA

[3] Univ Pittsburgh, Sch Med, Dept Pharmacol, Pittsburgh, PA 15213 USA

[4] Univ Pittsburgh, Sch Med, Dept Neurosci, Pittsburgh, PA 15213 USA

来源：

BRAIN RESEARCH | 2006年 / 1087卷

关键词：

rat; appetite; fenfluramine; hypothalamus; neuropeptide; mRNA;

D O I：

10.1016/j.brainres.2006.02.129

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Appetite suppressants lose efficacy when given chronically; the mechanisms are unknown. We gave male rats once-daily DL-fenfluramine (DL-FEN, 5 mg/kg, i.p.) injections for 15 days and measured mRNA expression of corticotropin releasing factor (CRF), neuropeptide Y (NPY) and proopiornelanocortin (POMC) in hypothalamic neurons on days 1, 2 and 15. DL-FEN decreased food intake on days 1-2 but not on day 15. The drug increased CRF mRNA and decreased NPY mRNA on days 1-2; on day 15, NPY mRNA was normal, but CRF mRNA remained elevated. No changes occurred in POMC mRNA. Thus, only the NPY mRNA response to DL-FEN correlated with changes in food intake over time in a manner consistent with the known effects of NPY on food intake. (c) 2006 Elsevier B.V. All rights reserved.

引用

收藏

页码：83 / 86

页数：4

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