A Novel Targeted Approach to the Treatment of Hemophagocytic Lymphohistiocytosis (HLH) with an Anti-Interferon Gamma (IFNγ) Monoclonal Antibody (mAb), NI-0501: First Results from a Pilot Phase 2 Study in Children with Primary HLH

被引：52

作者：

Jordan, Michael ^{[1
,2
]}

Locatelli, Franco ^{[3
]}

Allen, Carl ^{[4
,5
]}

De Benedetti, Fabrizio ^{[6
]}

Grom, Alexei A. ^{[7
]}

Ballabio, Maria ^{[8
]}

Ferlin, Walter Giovanni ^{[9
]}

De Min, Cristina ^{[8
]}

机构：

[1] Cincinnati Childrens Hosp Med Ctr, Div Cellular, Cincinnati, OH 45229 USA

[2] Cincinnati Childrens Hosp Med Ctr, Div Mol Immunol & BMT, Cincinnati, OH 45229 USA

[3] IRCCS Osped Pediat Bambino Gesu, Dept Pediat Hematol & Oncol, Rome, Italy

[4] Texas Childrens Hosp, Texas Childrens Canc Ctr, Houston, TX 77030 USA

[5] Texas Childrens Hosp, Texas Childrens Hematol Ctr, Houston, TX 77030 USA

[6] IRCCS Osped Pediatrico Bambino Gesu, Dept Rheumatol, Rome, Italy

[7] Cincinnati Childrens Hosp, Cincinnati, OH USA

[8] Novimmune SA, Clin Dev, Geneva, Switzerland

[9] Novimmune SA, Exploratory Sci & Translat Med, Geneva, Switzerland

[10] NI 0501 04 Study, Geneva, Switzerland

来源：

关键词：

D O I：

10.1182/blood.V126.23.LBA-3.LBA-3

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

引用

页数：3