Structure-activity relationship studies of chloromethyl ketone derivatives for selective human chymase inhibitors

被引：20

作者：

Hayashi, Y ^{[1
]}

Iijima, K

Katada, J

Kiso, Y

机构：

[1] Kyoto Pharmaceut Univ, Dept Med Chem, Yamashina Ku, Kyoto 6078412, Japan

[2] Nippon Steel Corp Ltd, Adv Technol Res Labs, Life Sci Res Ctr, Nakahara Ku, Kawasaki, Kanagawa 2110035, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(99)00659-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Based on the SAR study of a classical chloromethyl ketone derivative, Z-PheCH(2)Cl 1, a series of compounds were synthesized. Among all the derivatives, compound 21 was found to be a potent human chymase inhibitor with no inhibitory activity against human leukocyte cathepsin G. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：199 / 201

页数：3

共 17 条

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