Translational repressors in Drosophila

被引：18

作者：

Dean, KA

Aggarwal, AK

Wharton, RP

机构：

[1] Duke Univ, Med Ctr, Howard Hughes Med Inst, Dept Mol Genet & Microbiol, Durham, NC 27710 USA

[2] CUNY Mt Sinai Sch Med, Dept Physiol & Biophys, Struct Biol Program, New York, NY 10029 USA

来源：

TRENDS IN GENETICS | 2002年 / 18卷 / 11期

关键词：

D O I：

10.1016/S0168-9525(02)02792-0

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Translational regulation is an important aspect of gene regulation, particularly during early development of the fruit fly embryo when transcriptional mechanisms are untenable. Study of pattern formation and dosage compensation has identified several repressors that bind discrete sites in the untranslated portions of target mRNAs. These repressors do not work in isolation - each binds multiple sites in the appropriate mRNA, and the resulting RNA-protein complexes appear to recruit co-repressors by a variety of mechanisms.

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收藏

页码：572 / 577

页数：6

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