Progression of Mild Cognitive Impairment to Alzheimer's Disease: Improved Diagnostic Value of the Combined Use of N200 Latency and β-Amyloid(1-42) Levels

被引:28
作者
Papaliagkas, V. T. [1 ]
Anogianakis, G. [1 ]
Tsolaki, M. N. [2 ]
Koliakos, G. [3 ]
Kimiskidis, V. K. [2 ]
机构
[1] Aristotle Univ Thessaloniki, Fac Med, Dept Expt Physiol, GR-54124 Thessaloniki, Greece
[2] Aristotle Univ Thessaloniki, G Papanikolaou Hosp, Dept Neurol 3, GR-54124 Thessaloniki, Greece
[3] Aristotle Univ Thessaloniki, Fac Med, Biol Chem Lab, GR-54124 Thessaloniki, Greece
关键词
Mild cognitive impairment; Alzheimer's disease; beta-Amyloid(1-42); Auditory event-related potentials; N200; latency; CLINICAL-DIAGNOSIS; CSF BIOMARKERS; POTENTIALS; PROTEIN; TAU;
D O I
10.1159/000229023
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Background/Aims: The aim of this study was to investigate the role of cerebrospinal fluid beta-amyloid(1-42) levels and auditory event-related potentials (AERPs) in the progress of mild cognitive impairment (MCI) to Alzheimer's disease (AD). Methods: In 53 MCI patients, lumbar puncture was performed and beta-amyloid(1-42) levels were determined. Twenty patients were reexamined after 11 months. During this period, 5 of them progressed to AD. Neuropsychological and ERP analyses were performed on all patients during both baseline and endpoint examinations. Results: Compared to stable MCI patients, those that progressed to AD had significantly lower beta-amyloid(1-42) levels (Mann-Whitney test, Z = -2.952, p = 0.003; effect size r = -0.41) and significantly prolonged N200 latencies (Mann-Whitney test, Z = -3.561, p < 0.001, effect size r = -0.49). From ERP variables, only the N200 latency significantly correlated with beta-amyloid(1-42) levels (baseline examination: r(s) = -0.421, p = 0.002; follow-up examination: r(s) = -0.574, p = 0.008). Conclusions: The combined use of these two parameters enabled discrimination of stable MCI patients from those who developed AD, with 100% sensitivity and specificity. Therefore, this method could be of high diagnostic value for the early diagnosis of AD. Copyright (c) 2009 S. Karger AG, Basel
引用
收藏
页码:30 / 35
页数:6
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