Concise synthesis of the cell cycle inhibitor demethoxyfumitremorgin C

被引：51

作者：

Wang, HS ^{[1
]}

Ganesan, A ^{[1
]}

机构：

[1] NATL UNIV SINGAPORE, INST MOL & CELL BIOL, SINGAPORE 119260, SINGAPORE

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 24期

关键词：

D O I：

10.1016/S0040-4039(97)00892-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reaction of the imine derived from L-tryptophan methyl ester and senecialdehyde with Fmoc-L-Pro-Cl induces an acyliminium Pictet-Spengler condensation, yielding a mixture of cis and trans tetrahydro-beta-carbolines. Deprotection of the cis product with concomitant diketopiperazine formation afforded the natural product in 20% overall yield. (C) 1997 Elsevier Science Ltd.

引用

页码：4327 / 4328

页数：2

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