Effect of Low-Magnitude Whole-Body Vibration Combined with Alendronate in Ovariectomized Rats: A Random Controlled Osteoporosis Prevention Study

被引：25

作者：

Chen, Guo-Xian ^{[1
,2
]}

Zheng, Shuai ^{[1
]}

Qin, Shuai ^{[3
]}

Zhong, Zhao-Ming ^{[1
]}

Wu, Xiu-Hua ^{[1
]}

Huang, Zhi-Ping ^{[1
]}

Li, Wei ^{[1
]}

Ding, Ruo-Ting ^{[1
]}

Yu, Hui ^{[1
]}

Chen, Jian-Ting ^{[1
]}

机构：

[1] Southern Med Univ, Nanfang Hosp, Dept Orthoped Spinal Surg, Guangzhou, Guangdong, Peoples R China

[2] First Hosp Putian City, Dept Orthoped, Putian City, Fujian Province, Peoples R China

[3] Peoples Hosp Zhuhai, Dept Ophthalmol, Zhuhai, Peoples R China

来源：

PLOS ONE | 2014年 / 9卷 / 05期

基金：

中国国家自然科学基金;

关键词：

POSTMENOPAUSAL BONE LOSS; LOW-LEVEL; MECHANICAL SIGNALS; MUSCLE STRENGTH; DOUBLE-BLIND; IN-VIVO; RESORPTION; FRACTURE; MARKERS; WOMEN;

D O I：

10.1371/journal.pone.0096181

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Background: Alendronate (ALE) is a conventional drug used to treat osteoporosis. Low-magnitude whole-body vibration (WBV) exercise has been developed as a potential treatment for osteoporosis. The aim of this study was to investigate whether low-magnitude WBV could enhance the protective effect of ALE on bone properties in ovariectomized rats. Methods: A total of 128 Sprague-Dawley rats were randomly divided into five groups (SHAM, OVX+VEH, OVX+WBV, OVX + ALE, OVX+ WBV+ALE). The level of WBV applied was 0.3 g at 45-55 Hz for 20 min/day, 5 day/week and for 3 months. ALE was administered in dose of 1 mg/Kg once a week. Every four weeks eight rats from each group were sacrificed and their blood and both tibiae were harvested. The expression of osteocalcin and CTX in serum was measured by enzyme-linked immunosorbent assay (ELISA) and the tibiae were subjected to metaphyseal three-point bending and mu CT analysis. Results: Osteocalcin rose after ovariectomy and was not appreciably changed by either alendronate or WBV alone or in combination. Alendronate treatment significantly prevented an increase in CTX. WBV alone treatment did not alter this effect. Compared with the OVX+WBV group, nearly all tested indices such as the BV/TV, TV apparent, Tb.N, Tb.Th, and Conn.D were higher in the OVX+ALE group at week 12. Compared with the OVX+WBV group, certain tested indices such as BV/TV, TV apparent, Tb.N, and Con.D, were higher in the OVX+WBV+ALE group at week 12. At week 12, tibiae treated with WBV+ALE exhibited a significantly higher Fmax compared to the OVX+VEH group, and a significant difference was also found in energy absorption between the OVX+WBV+ALE and OVX+VEH groups. Conclusions: Compared with the WBV, ALE was more effective at preventing bone loss and improved the trabecular architecture. However, WBV enhanced the effect of alendronate in ovariectomized rats by inducing further improvements in trabecular architecture.

引用

页数：8

共 57 条

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