Mechanisms of inhibition of the host interferon α/β-mediated antiviral responses by viruses

被引:101
作者
García-Sastre, A [1 ]
机构
[1] CUNY Mt Sinai Sch Med, Dept Microbiol, New York, NY 10029 USA
基金
美国国家卫生研究院;
关键词
interferon; interferon antagonist; innate immunity;
D O I
10.1016/S1286-4579(02)01583-6
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Complex multicellular organisms have evolved sophisticated mechanisms to prevent and control infection by pathogens. Among these mechanisms, the type I interferon or interferon alpha/beta system represents one of the first lines of defense against viral infections. Typically, viral infection induces the synthesis and secretion of interferon alpha/beta by the infected cell, which in turn activates signaling pathways leading to an antiviral state. As a counter measure, many viruses have developed intriguing mechanisms to evade the interferon alpha/beta system of the host. In this review, we will summarize recent research developments in this interesting field of virus-host cell interactions. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
引用
收藏
页码:647 / 655
页数:9
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