Use of metformin for prevention of ovarian hyperstimulation syndrome: a novel approach

被引：21

作者：

Khattab, Sherif

Fotouh, Ismail Aboul

Mohesn, Iman Abdel

Metwally, Mostapha

Moaz, Mohamed

机构：

[1] Cairo Univ, Misr Int Hosp, Egyptian Int Fertil Ctr, Dept Obstet & Gynecol, Cairo, Egypt

[2] Cairo Univ, Misr Int Hosp, Egyptian Int Fertil Ctr, IVF Lab, Cairo, Egypt

来源：

REPRODUCTIVE BIOMEDICINE ONLINE | 2006年 / 13卷 / 02期

关键词：

controlled clinical trial; IVF metformin; OHSS;

D O I：

10.1016/S1472-6483(10)60614-1

中图分类号：

R71 [妇产科学];

学科分类号：

100211 [妇产科学];

摘要：

In the present study, which includes 287 participants, metformin has been used by women undergoing IVF/intracytoplasmic sperm injection for more than 5 weeks before and during treatment and during luteal phase. There was no significant difference in number of gonadotrophins used, days of stimulation, number of oocytes retrieved, and number of embryos replaced. There was no significant difference in clinical pregnancy rate between both groups but there was significant reduction in the incidence of ovarian hyperstimulation syndrome (OHSS) in the group taking metformin. Metformin is a safe, cheap drug that can help in prevention of OHSS.

引用

收藏

页码：194 / 197

页数：4

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