Sunlight and the onset of skin cancer

被引：251

作者：

Brash, DE

机构：

[1] YALE UNIV,SCH MED,DEPT GENET,NEW HAVEN,CT 06520

[2] YALE UNIV,SCH MED,YALE COMPREHENS CANC CTR,NEW HAVEN,CT 06520

来源：

TRENDS IN GENETICS | 1997年 / 13卷 / 10期

关键词：

D O I：

10.1016/S0168-9525(97)01246-8

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The photons of sunlight precipitate a series of genetic events in skin leading to cancer. These events involve somatic mutations as well as inherited alleles. Competition between cell populations ensues, as a single mutated cell expands into a clone. Thus cancer involves both a single-cell problem and a many-cell problem; in skin cancer, sunlight appears to drive both.

引用

页码：410 / 414

页数：5

共 40 条

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