Cardioprotective activity of Hydrocotyle asiatica L. in ischemia-reperfusion induced myocardial infarction in rats

被引：17

作者：

Pragada, RR ^{[1
]}

Veeravalli, KK ^{[1
]}

Chowdary, KPR ^{[1
]}

Routhu, K ^{[1
]}

机构：

[1] Andhra Univ, Dept Pharmaceut Sci, Div Pharmacol, Visakhapatnam 530003, Andhra Pradesh, India

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2004年 / 93卷 / 01期

关键词：

Hydrocotyle asiatica L; cardioprotective; ischemia; reperfusion; infarction;

D O I：

10.1016/j.jep.2004.03.025

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

The alcoholic extract of hydrocotyle asiatica Linn. (Hydrocotyle asiatica L.) whole plant was evaluated for carchoprotective activity against ischemia-reperfusion induced myocardial infarction in rats. Cardioprotective activity was studied by measuring infarct size and estimating lipid peroxide levels in serum and heart tissue. A lead II electrocardiogram was monitored at various intervals throughout the experiment. A dose (100-1000 mg kg(-1)) dependent reduction in percent left ventricle necrosis (PLVN) as well as in lipid peroxide levels was observed in rats treated with alcoholic extract of Hydrocotyle asiatica L. orally for 7 days compared to control animals. The study strongly suggests the cardioprotective activity of Hydrocotyle asiatica L. in limiting ischemia-reperfusion induced myocardial injury. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：105 / 108

页数：4

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