Mitochondria and reactive oxygen species

被引:902
作者
Kowaltowski, Alicia J. [2 ]
de Souza-Pinto, Nadja C. [2 ]
Castilho, Roger F. [1 ]
Vercesi, Anibal E. [1 ]
机构
[1] Univ Estadual Campinas, Fac Ciencias Med, Dept Patol Clin, BR-13083887 Campinas, SP, Brazil
[2] Univ Sao Paulo, Inst Quim, Dept Bioquim, BR-01498 Sao Paulo, Brazil
关键词
Mitochondria; Oxidative stress; Free radicals; Respiration; Uncoupling; Electron transport chain; Energy metabolism; NITRIC-OXIDE SYNTHASE; SENSITIVE K+ CHANNEL; ELECTRON-TRANSPORT CHAIN; ALPHA-KETOGLUTARATE DEHYDROGENASE; HYDROGEN-PEROXIDE GENERATION; SKELETAL-MUSCLE MITOCHONDRIA; ISCHEMIA-REPERFUSION INJURY; CULTURED SKIN FIBROBLASTS; PROGRAMMED CELL-DEATH; REPLICATIVE LIFE-SPAN;
D O I
10.1016/j.freeradbiomed.2009.05.004
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Mitochondria are a quantitatively relevant source of reactive oxygen species (ROS) in the majority of cell types. Here we review the sources and metabolism of ROS in this organelle, including the conditions that regulate the production of these species, such as mild uncoupling, oxygen tension, respiratory inhibition, Ca2+ and K+ transport, and mitochondrial content and morphology. We discuss substrate-, tissue-, and organism-specific characteristics of mitochondrial oxidant generation. Several aspects of the physiological and pathological roles of mitochondrial ROS production are also addressed. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码:333 / 343
页数:11
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