Uncovering new complexities in mast cell signaling

被引：26

作者：

Nadler, MJS ^{[1
]}

Kinet, JP

机构：

[1] Harvard Univ, Sch Med, Boston, MA 02215 USA

[2] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

来源：

NATURE IMMUNOLOGY | 2002年 / 3卷 / 08期

关键词：

D O I：

10.1038/ni0802-707

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

FcεRI activation of mast cells was thought to be Lyn-dependent. It now appears that FcεRI also uses a Fyn kinase–dependent pathway that is essential for mast cell degranulation.

引用

页码：707 / 708

页数：2

共 11 条

[1]

Costello PS, 1996, ONCOGENE, V13, P2595

[2]

EISEMAN E, 1992, NATURE, V355, P78

[3] Essential role for Gab2 in the allergic response [J].

Gu, HH ;

Saito, K ;

Klaman, LD ;

Shen, JQ ;

Fleming, T ;

Wang, YP ;

Pratt, JC ;

Lin, GS ;

Lim, B ;

Kinet, JP ;

Neel, BG .

NATURE, 2001, 412 (6843) :186-190

[4] Redundant and opposing functions of two tyrosine kinases, Btk and Lyn, in mast cell activation [J].

Kawakami, Y ;

Kitaura, J ;

Satterthwaite, AB ;

Kato, RM ;

Asai, K ;

Hartman, SE ;

Maeda-Yamamoto, M ;

Lowell, CA ;

Rawlings, DJ ;

Witte, ON ;

Kawakami, T .

JOURNAL OF IMMUNOLOGY, 2000, 165 (03) :1210-1219

[5]

Nadler M J, 2000, Adv Immunol, V76, P325

[6]

Nishizumi H, 1997, J IMMUNOL, V158, P2350

[7]

OZAWA K, 1993, J BIOL CHEM, V268, P1749

[8] Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation [J].

Parravicini, V ;

Gadina, M ;

Kovarova, M ;

Odom, S ;

Gonzalez-Espinosa, C ;

Furumoto, Y ;

Saitoh, S ;

Samelson, LE ;

O'Shea, JJ ;

Rivera, J .

NATURE IMMUNOLOGY, 2002, 3 (08) :741-748

[9]

Pivniouk VI, 1999, J CLIN INVEST, V103, P1737

[10] LAT is essential for FcεRI-mediated mast cell activation [J].

Saitoh, S ;

Arudchandran, R ;

Manetz, TS ;

Zhang, WG ;

Sommers, CL ;

Love, PE ;

Rivera, J ;

Samelson, LE .

IMMUNITY, 2000, 12 (05) :525-535

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