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Cytochrome P450 epoxygenases as EDHF synthase(s)

被引：115
作者：
Fleming, I [1 ]
机构：
[1] Goethe Univ Frankfurt, Inst Kardiovaskulare Physiol, D-60590 Frankfurt, Germany
来源：
PHARMACOLOGICAL RESEARCH | 2004年 / 49卷 / 06期
关键词：
angiogenesis; calcium-dependent potassium channels epoxyeicosatrienoic acids; gap junctions; soluble epoxide hydrolase;
D O I：
10.1016/j.phrs.2003.11.016
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The metabolism of arachidonic acid by cytochrome P450 (CYP) epoxygenases generates epoxyeicosatrienoic acids (EETs) which affect numerous cellular process including Ca2+ signaling and the activity of Ca2+-dependent K+ channels. The expression of the CYP epoxygenase(s) that generate EETs in endothelial cells is not constitutive but is determined by a number of physical (fluid shear stress and cyclic stretch) and pharmacological stimuli which also affect responses attributed to an endothelium-derived hyperpolarizing factor (EDHF). This review summarizes the role played by EETs, and the enzymes that generate and metabolize them, in EDHF-mediated responses. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：525 / 533
页数：9
相关论文
共 110 条
  • [1] ALVAREZ J, 1992, J BIOL CHEM, V267, P11789
  • [2] Dual targeting of cytochrome P4502B1 to endoplasmic reticulum and mitochondria involves a novel signal activation by cyclic AMP-dependent phosphorylation at Ser128
    Anandatheerthavarada, HK
    Biswas, G
    Mullick, J
    Sepuri, NBV
    Otvos, L
    Pain, D
    Avadhani, NG
    [J]. EMBO JOURNAL, 1999, 18 (20) : 5494 - 5504
  • [3] Endothelium-derived hyperpolarizing factor in human internal mammary artery is 11,12-epoxyeicosatrienoic acid and causes relaxation by activating smooth muscle BKCa channels
    Archer, SL
    Gragasin, FS
    Wu, XC
    Wang, SH
    McMurtry, S
    Kim, DH
    Platonov, M
    Koshal, A
    Hashimoto, K
    Campbell, WB
    Falck, JR
    Michelakis, ED
    [J]. CIRCULATION, 2003, 107 (05) : 769 - 776
  • [4] Possible role of P-450 metabolite of arachidonic acid in vasodilator mechanism of angiotensin II type 2 receptor in the isolated microperfused rabbit afferent arteriole
    Arima, S
    Endo, Y
    Yaoita, H
    Omata, K
    Ogawa, S
    Tsunoda, K
    Abe, M
    Takeuchi, K
    Abe, K
    Ito, S
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1997, 100 (11) : 2816 - 2823
  • [5] Epoxyeicosatrienoic acids activate a high-conductance, Ca2+-dependent K+ channel on pig coronary artery endothelial cells
    Baron, A
    Frieden, M
    Beny, JL
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 1997, 504 (03): : 537 - 543
  • [6] Cytochrome P4502C expression and EDHF-mediated relaxation in porcine coronary arteries is increased by cortisol
    Bauersachs, J
    Christ, M
    Ertl, G
    Michaelis, UR
    Fisslthaler, B
    Busse, R
    Fleming, I
    [J]. CARDIOVASCULAR RESEARCH, 2002, 54 (03) : 669 - 675
  • [7] DISPLAY OF THE CHARACTERISTICS OF ENDOTHELIUM-DERIVED HYPERPOLARIZING FACTOR BY A CYTOCHROME P450-DERIVED ARACHIDONIC-ACID METABOLITE IN THE CORONARY MICROCIRCULATION
    BAUERSACHS, J
    HECKER, M
    BUSSE, R
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 1994, 113 (04) : 1548 - 1553
  • [8] Nitric oxide attenuates the release of endothelium-derived hyperpolarizing factor
    Bauersachs, J
    Popp, R
    Hecker, M
    Sauer, E
    Fleming, I
    Busse, R
    [J]. CIRCULATION, 1996, 94 (12) : 3341 - 3347
  • [9] EDHF:: bringing the concepts together
    Busse, R
    Edwards, G
    Félétou, M
    Fleming, I
    Vanhoutte, PM
    Weston, AH
    [J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 2002, 23 (08) : 374 - 380
  • [10] Aged spontaneously hypertensive rats exhibit a selective loss of EDHF-mediated relaxation in the renal artery
    Büssemaker, E
    Popp, R
    Fisslthaler, B
    Larson, CM
    Fleming, I
    Busse, R
    Brandes, RP
    [J]. HYPERTENSION, 2003, 42 (04) : 562 - 568
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