The uptake of cholesterol at the small-intestinal brush border membrane is inhibited by apolipoproteins

被引：21

作者：

Boffelli, D

Compassi, S

Werder, M

Weber, FE

Phillips, MC

Schulthess, G

Hauser, H

机构：

[1] ETH ZENTRUM, DEPT BIOCHEM, CH-8092 ZURICH, SWITZERLAND

[2] UNIV ZURICH HOSP, MED POLIKLIN, DEPT INNERE MED, CH-8091 ZURICH, SWITZERLAND

[3] ALLEGHENY UNIV HLTH SCI, MCP, HAHNEMANN MED SCH, DEPT BIOCHEM, PHILADELPHIA, PA 19129 USA

来源：

FEBS LETTERS | 1997年 / 411卷 / 01期

关键词：

cholesterol; intestinal absorption; brush border membrane; inhibition; apolipoprotein;

D O I：

10.1016/S0014-5793(97)00658-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The uptake of free and esterified cholesterol at the brush border membrane is protein-mediated. Here we show that this sterol uptake is effectively inhibited by exchangeable serum apolipoproteins. Binding of the apolipoprotein to the brush border membrane mediates the inhibitory effect. Evidence is presented to show that the structural motif responsible for the inhibition is the amphipathic alpha-helix. (C) 1997 Federation of European Biochemical Societies.

引用

页码：7 / 11

页数：5

共 24 条

[1]

ANANTHARAMAIAH GM, 1986, METHOD ENZYMOL, V128, P627

[2] STRUCTURAL MODELS OF HUMAN APOLIPOPROTEIN-A-I [J].