Antioxidant enzyme determination and a study of lipid peroxidation in renal transplantation

被引：24

作者：

Fernandez, RP ^{[1
]}

Mateo, MCM ^{[1
]}

De Vega, L ^{[1
]}

Bustamante, JB ^{[1
]}

Herrero, M ^{[1
]}

Munguira, EB ^{[1
]}

机构：

[1] Univ Valladolid, Sch Sci, Dept Biochem, E-47005 Valladolid, Spain

来源：

RENAL FAILURE | 2002年 / 24卷 / 03期

关键词：

catalase; superoxide dismutase (SOD); malondialdehyde (MDA); renal transplantation;

D O I：

10.1081/JDI-120005369

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The aim of this study was to evaluate the antioxidant enzymes, catalase (CAT) and superoxide dismutase (SOD), in renal transplant patients and at the same time to report on the degree of lipid peroxidation observed in these patients. In order to do so we measured erythrocyte malondialdehyde (MDA), a product of lipid peroxidation. These measurements were made at different times: before the transplant, 48 h after the transplant, a week after the transplant and two weeks after the transplant. The values reported were compared with a control group. The results showed that there was a higher MDA level in the transplant group than in the control group one week after the transplant. In addition, two weeks after the transplant, the activities of CAT and SOD were higher in the transplant group than in the control group.

引用

页码：353 / 359

页数：7

共 17 条

[1]

AEBY H, 1984, METHOD ENZYMOL, V5, P105

[2] ANTIOXIDANT ENZYMES AND LIPOPEROXIDE IN BLOOD IN UREMIC CHILDREN AND ADOLESCENTS [J].

ASAYAMA, K ;

SHIKI, Y ;

ITO, H ;

HASEGAWA, O ;

MIYAO, A ;

HAYASHIBE, H ;

DOBASHI, K ;

KATO, K .

FREE RADICAL BIOLOGY AND MEDICINE, 1990, 9 (02) :105-109

[3]

BALASHOVA TS, 1992, TERAPEVT ARKH, V64, P66

[4]

CHIU D, 1982, SEMIN HEMATOL, V26, P257

[5] Decreased total antioxidant capacity but normal lipid hydroperoxide concentrations in sera of critically ill patients [J].

Dasgupta, A ;

Malhotra, D ;

Levy, H ;

Marcadis, D ;

Blackwell, W ;

Johnston, D .

LIFE SCIENCES, 1996, 60 (4-5) :335-340

[6]

DAVENPORT A, 1995, CLIN TRANSPLANT, V9, P171

[7]

DELCANTO E, 1997, KIDNEY INT, V4, P52

[8] INFLUENCE OF CONTINUOUS AMBULATORY PERITONEAL-DIALYSIS ON THE ANEMIA OF ENDSTAGE RENAL-DISEASE [J].

DEPAEPE, MBJ ;

SCHELSTRAETE, KHG ;

RINGOIR, SMG ;

LAMEIRE, NH .

KIDNEY INTERNATIONAL, 1983, 23 (05) :744-748

[9]

HALLIWELL B, 1989, FREE RADICAL BIO MED, V1, P13

[10] Melatonin - An antioxidant protects against cyclosporine-induced nephrotoxicity [J].

Kumar, KV ;

Naidu, MUR ;

Shifow, AA ;

Prayag, A ;

Ratnakar, KS .

TRANSPLANTATION, 1999, 67 (07) :1065-1068

← 1 2 →