PDGF receptor kinase inhibitors for the treatment of PDGF driven diseases

被引：76

作者：

Levitzki, A ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Alexander Silberman Inst Life Sci, Dept Biol Chem, Unit Cellular Signaling, IL-91904 Jerusalem, Israel

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2004年 / 15卷 / 04期

关键词：

PDGF; tyrphostins; restenosis; cancer;

D O I：

10.1016/j.cytogfr.2004.03.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

PDGF and its receptors are involved in a variety of diseases: cancers, atherosclerosis, balloon injury induced restenosis, pulmonary fibrosis and more. In all cases enhanced signaling of the receptor is the hallmark. In some cases, like chronic myelomonocyatic leukemia (CMML), the persistent PDGFR signaling is essential for the survival of the cancer cell. These findings induced the research community as well as the pharmaceutical industry to develop agents that block PDGFR signaling. The possible utilization of PDGFR kinase inhibitors as anti-restenosis agents is likely to move ahead of the utilization of these agents to treat human malignancies. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：229 / 235

页数：7

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