Tolerance to intravenous administration of heparin and heparinoid in a patient with delayed-type hypersensitivity to heparins and heparinoids

被引：36

作者：

Boehncke, WH ^{[1
]}

Weber, L ^{[1
]}

Gall, H ^{[1
]}

机构：

[1] UNIV ULM,DEPT DERMATOL,D-89081 ULM,GERMANY

来源：

CONTACT DERMATITIS | 1996年 / 35卷 / 02期

关键词：

heparin; heparinoid; delayed-type hypersensitivity; intravenous tolerance; drug reactions; anticoagulants;

D O I：

10.1111/j.1600-0536.1996.tb02293.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Delayed-type hypersensitivity reactions to subcutaneously (s.c.) injected heparins are common. Since similar reactions usually occur to different heparin preparations, semisynthetic heparinoids might be a therapeutic alternative. We report a patient exhibiting eczematous reactions to heparins as well as heparinoids; delayed-type hypersensitivity was demonstrated by intracutaneous (i.c.) and patch tests, as well as by s.c. provocation. Remarkably, intravenous (i.v.) administration of heparin as well as heparinoid was well-tolerated. (C) Munksgaard, 1996.

引用

页码：73 / 75

页数：3

共 6 条

[1]

BIRCHER AJ, 1993, ALLERGOLOGIE, V16, P268

[2] A REVIEW OF CONTACT-DERMATITIS ASSOCIATED WITH TRANSDERMAL THERAPEUTIC SYSTEMS [J].