Pathways of chaperone-mediated protein folding in the cytosol

被引：902

作者：

Young, JC

Agashe, VR

Siegers, K

Hartl, FU

机构：

[1] Max Planck Inst Biochem, Dept Cellular Biochem, D-82152 Martinsried, Germany

[2] McGill Univ, Dept Biochem, Montreal, PQ H3C 1Y6, Canada

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2004年 / 5卷 / 10期

关键词：

D O I：

10.1038/nrm1492

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cells are faced with the task of folding thousands of different polypeptides into a wide range of conformations. For many proteins, the folding process requires the action of molecular chaperones. In the cytosol of prokaryotic and eukaryotic cells, molecular chaperones of different structural classes form a network of pathways that can handle substrate polypeptides from the point of initial synthesis on ribosomes to the final stages of folding.

引用

收藏

页码：781 / 791

页数：11

相关论文

共 143 条

[1] Function of trigger factor and DnaK in multidomain protein folding: Increase in yield at the expense of folding speed [J].

Agashe, VR ;

Guha, S ;

Chang, HC ;

Genevaux, P ;

Hayer-Hartl, M ;

Stemp, M ;

Georgopoulos, C ;

Hartl, FU ;

Barral, JM .

CELL, 2004, 117 (02) :199-209

[2] Ubiquitylation of BAG-1 suggests a novel regulatory mechanism during the sorting of chaperone substrates to the proteasome [J].

Alberti, S ;

Demand, J ;

Esser, C ;

Emmerich, N ;

Schild, H ;

Höhfeld, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (48) :45920-45927

[3] PRINCIPLES THAT GOVERN FOLDING OF PROTEIN CHAINS [J].

ANFINSEN, CB .

SCIENCE, 1973, 181 (4096) :223-230

[4] Role of the myosin assembly protein UNC-45 as a molecular chaperone for myosin [J].

Barral, JM ;

Hutagalung, AH ;

Brinker, A ;

Hartl, FU ;

Epstein, HF .

SCIENCE, 2002, 295 (5555) :669-671

[5] Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function [J].

Basso, AD ;

Solit, DB ;

Chiosis, G ;

Giri, B ;

Tsichlis, P ;

Rosen, N .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (42) :39858-39866

[6]

Becker J, 1996, MOL CELL BIOL, V16, P4378

[7] INTERACTION OF HSP-70 WITH NEWLY SYNTHESIZED PROTEINS - IMPLICATIONS FOR PROTEIN FOLDING AND ASSEMBLY [J].

BECKMANN, RP ;

MIZZEN, LA ;

WELCH, WJ .

SCIENCE, 1990, 248 (4957) :850-854

[8] Localization of the trigger factor binding site on the ribosomal 50 S subunit [J].

Blaha, G ;

Wilson, DN ;

Stoller, G ;

Fischer, G ;

Willumeit, R ;

Nierhaus, KH .

JOURNAL OF MOLECULAR BIOLOGY, 2003, 326 (03) :887-897

[9] HSP82 IS AN ESSENTIAL PROTEIN THAT IS REQUIRED IN HIGHER CONCENTRATIONS FOR GROWTH OF CELLS AT HIGHER TEMPERATURES [J].

BORKOVICH, KA ;

FARRELLY, FW ;

FINKELSTEIN, DB ;

TAULIEN, J ;

LINDQUIST, S .

MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (09) :3919-3930

[10] Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system [J].

Brychzy, A ;

Rein, T ;

Winklhofer, KF ;

Hartl, FU ;

Young, JC ;

Obermann, WMJ .

EMBO JOURNAL, 2003, 22 (14) :3613-3623

← 1 2 3 4 5 6 7 8 9 10 →