Relevance of the application of pharmacokinetic-pharmacodynamic modelling concepts in drug development - The 'Wooden Shoe' paradigm

被引：84

作者：

Breimer, DD

Danhof, M

机构：

[1] Leiden-Amsterdam Ctr. Drug Research, Division of Pharmacology, Leiden Univ., Sylvius Laboratories, 2300 RA Leiden

来源：

CLINICAL PHARMACOKINETICS | 1997年 / 32卷 / 04期

关键词：

D O I：

10.2165/00003088-199732040-00001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

[No abstract available]

引用

页码：259 / 267

页数：9

共 35 条

[1] Efficacy measures: Surrogates or clinical outcomes? [J].

Blue, JW ;

Colburn, WA .

JOURNAL OF CLINICAL PHARMACOLOGY, 1996, 36 (09) :767-770

[2]

BOUDIER HAJ, 1983, 1 EUR M HYP MAY 24 J

[3] PHARMACOKINETIC-PHARMACODYNAMIC MODELING OF THE INTERACTION BETWEEN FLUMAZENIL AND MIDAZOLAM IN VOLUNTEERS BY APERIODIC EEG ANALYSIS [J].

BREIMER, LTM ;

BURM, AGL ;

DANHOF, M ;

HENNIS, PJ ;

VLETTER, AA ;

DEVOOGT, JWH ;

SPIERDIJK, J ;

BOVILL, JG .

CLINICAL PHARMACOKINETICS, 1991, 20 (06) :497-508

[4]

COLLINS JM, 1993, INTEGRATION OF PHARMACOKINETICS, PHARMACODYNAMICS, AND TOXICOKINETICS IN RATIONAL DRUG DEVELOPMENT, P49

[5] PHARMACOKINETIC-PHARMACODYNAMIC MODELING IN PRECLINICAL INVESTIGATIONS - PRINCIPLES AND PERSPECTIVES [J].

DANHOF, M ;

MANDEMA, JW ;

HOOGERKAMP, A ;

MATHOT, RAA .

EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 1993, 18 (01) :41-47

[6] COMPARISON OF 4 BASIC MODELS OF INDIRECT PHARMACODYNAMIC RESPONSES [J].

DAYNEKA, NL ;

GARG, V ;

JUSKO, WJ .

JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 1993, 21 (04) :457-478

[7]

Derendorf H., 1995, Handbook of pharmacokinetic/pharmacodynamic correlation

[8] PHARMACOKINETIC PHARMACODYNAMIC MODELING OF CNS DRUG EFFECTS - AN OVERVIEW [J].

DINGEMANSE, J ;

DANHOF, M ;

BREIMER, DD .

PHARMACOLOGY & THERAPEUTICS, 1988, 38 (01) :1-52

[9] Remifentanil versus alfentanil - Comparative pharmacokinetics and pharmacodynamics in healthy adult male volunteers [J].

Egan, TD ;

Minto, CF ;

Hermann, DJ ;

Barr, J ;

Muir, KT ;

Shafer, SL .

ANESTHESIOLOGY, 1996, 84 (04) :821-833

[10] SIMULTANEOUS MODELING OF PHARMACOKINETICS AND PHARMACODYNAMICS WITH A NONPARAMETRIC PHARMACODYNAMIC MODEL [J].

FUSEAU, E ;

SHEINER, LB .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 1984, 35 (06) :733-741

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