The Aspergillus nidulans genes chsA and chsD encode chitin syntheses which have redundant functions in conidia formation

被引:17
作者
Motoyama, T [1 ]
Fujiwara, M [1 ]
Kojima, N [1 ]
Horiuchi, H [1 ]
Ohta, A [1 ]
Takagi, M [1 ]
机构
[1] UNIV TOKYO,DEPT BIOTECHNOL,BUNKYO KU,TOKYO 113,JAPAN
来源
MOLECULAR & GENERAL GENETICS | 1996年 / 251卷 / 04期
关键词
chitin synthase; multigene family; cell wall; conidia; Aspergillus nidulans;
D O I
10.1007/s004380050188
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We previously isolated three chitin synthase genes (chsA, chsB, and chsC) from Aspergillus nidulans. In the present work, we describe the isolation and characterization of another chitin synthase gene, named chsD, from A, nidulans. Its deduced amino acid sequence shows 56.7% and 55.9% amino acid identity, respectively, with Call of Saccharomyces cerevisiae and Chs3 of Candida albicans. Disruption of chsD caused no defect in cell growth or morphology during the asexual cycle and caused no decrease in chitin content in hyphae. However, double disruption of chsA and chsD caused a remarkable decrease in the efficiency of conidia formation, while double disruption of chsC and chsD caused no defect. Thus it appears that chsA and chsD serve redundant functions in conidia formation.
引用
收藏
页码:442 / 450
页数:9
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